Results 61 to 70 of about 708,087 (381)

Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

Frontiers in Pharmacology, 2017
Slow and continuous release of H2S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells.
Zheng-Wei Lee, Xin-Yi Teo, Zhi J. Song, Dawn S. Nin, Dawn S. Nin, Wisna Novera, Bok A. Choo, Bok A. Choo, Brian W. Dymock, Brian W. Dymock, Philip K. Moore, Philip K. Moore, Ruby Y.-J. Huang, Ruby Y.-J. Huang, Ruby Y.-J. Huang, Lih-Wen Deng, Lih-Wen Deng, Lih-Wen Deng   +17 more
doaj   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Estudo piloto sobre a eficácia do losartan no tratamento do fenômeno de Raynaud (FRy) e correlação com alterações na microcirculação em pacientes com esclerose sistêmica (ES) Pilot study on losartan efficacy in the treatment of Raynaud's phenomenon (RP) and correlation with microcirculation alterations in patients with systemic sclerosis (SSc)

Revista Brasileira de Reumatologia, 2005
OBJETIVOS: Avaliar a eficácia do losartan no tratamento do fenômeno de Raynaud (FRy) em pacientes com FRy secundário à esclerose sistêmica (ES). Avaliamos também as anormalidades bioquímicas da microcirculação, através de dosagem da lacticemia de polpa ...
Cristiane Kayser, Marla Francisca dos Santos, Luís Eduardo C. Andrade   +2 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Lactate Sensors on Flexible Substrates

Biosensors, 2016
Lactate detection by an in situ sensor is of great need in clinical medicine, food processing, and athletic performance monitoring. In this paper, a flexible, easy to fabricate, and low-cost biosensor base on lactate oxidase is presented. The fabrication
Xuesong Yang, Timothy Fu, Pavan Kumar Kota, Maggie Tjia, Cuong Manh Nguyen, Jung-Chih Chiao   +5 more
doaj   +1 more source

Predictors of Intensive Care Unit admission in patients with coronavirus disease 2019 (COVID-19)

Monaldi Archives for Chest Disease, 2020
Italy is currently experiencing an epidemic of coronavirus disease 2019 (Covid-19). Aim of our study is to identify the best predictors of Intensive Care Unit (ICU) admission in patients with Covid-19.
Maria Viviana Carlino, Natja Valenti, Flavio Cesaro, Anita Costanzo, Giovanna Cristiano, Mario Guarino, Alfonso Sforza   +6 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Effects of caffeine on time to exhaustion in exercise performed below and above the anaerobic threshold

Brazilian Journal of Medical and Biological Research, 1998
Controversy still exists concerning the potential ergogenic benefit of caffeine (CAF) for exercise performance. The purpose of this study was to compare the effects of CAF ingestion on endurance performance during exercise on a bicycle ergometer at two ...
B.S. Denadai, M.L.D.R. Denadai
doaj   +1 more source

Taopatch® combined with home-based training protocol to prevent sedentary lifestyle and biochemical changes in MS patients during COVID-19 pandemic

European Journal of Translational Myology, 2021
In Multiple sclerosis (MS) it is important to preserve the residual physiological functions of subjects. The aim of the present study was to investigate the influence of nanotechnological device treatment combined with home-based training program (TP) on
Alessandra Amato, Giuseppe Messina, Kaltrina Feka, Diego Genua, Paolo Ragonese, Dorota Kostrzewa-Nowak , Francesco Fischetti, Angelo Iovane, Patrizia Proia   +8 more
doaj   +1 more source

Comparison of d and l-lactate content in cow and camel milk [PDF]

, 2015
Lactate is the product of fermentation of lactose in the digestive tract of milk consumers. The lactate has benef icial effect on health for the regulation of the milk protein digestion and calcium absorption. However, lactate has two stereoisomere named
Akhmetsadykova, Shynar, Baubekova, Almagul, Faye, Bernard, Kalimbetova, A., Konuspayeva, Gaukhar, Sandugash,   +5 more
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