Results 111 to 120 of about 60,229 (277)

Superior machine learning model for post-cardiac arrest mortality prediction: a MIMIC-IV cohort study

Resuscitation Plus
Background: Post-cardiac arrest syndrome carries substantial mortality despite advances in resuscitation. We developed a machine learning model to predict 28-day mortality using comprehensive clinical data.
Danxia Chen, Guode Li, Qinqin Shu, Junlin Huang, Weifeng Yuan, Yan Li   +5 more
doaj   +1 more source

Two-Hour Lactate Clearance Predicts Negative Outcome in Patients with Cardiorespiratory Insufficiency

Critical Care Research and Practice, 2010
Objective. To evaluate 2-hour lactate clearance as a prognostic marker in acute cardiorespiratory insufficiency. Design. Prospective observational study. Setting.
Sean Scott, Vittorio Antonaglia, Giovanna Guiotto, Fiorella Paladino, Fernando Schiraldi   +4 more
doaj   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Peri-transplant lactate levels and delayed lactate clearance as predictive factors for poor outcomes after liver transplantation: A propensity score-matched study

, 2019
This study aimed to investigate risk factors for early allograft dysfunction (EAD) and outcomes after liver transplantation (LT), focusing on peri-transplant lactate clearance.
Shunji Nagai, Abouljoud, Marwan, Safwan, Mohamed, Marwan S. Abouljoud, Abouljoud, Marwan S, Kazuhiro Takahashi, Syed‐Mohammed R. Jafri, Mohamed Safwan, Takahashi, Kazuhiro, Jafri, Syed-Mohammed, Nagai, Shunji   +10 more
core   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Lactate Inhibits Macrophage Phagocytosis and Bacterial Clearance During Polymicrobial Sepsis

, 2022
Introduction: Sepsis is a life-threatening disease that is characterized by organ dysfunction and dysregulated host innate and inflammatory responses to the infection.
Ha, Tuanzhu, Williams, David L., Fan, Min, Gill, Patrick S., Yang, Kun, Wang, Xiaohui, Li, Chuanfu   +6 more
core  

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Usefulness of post-reperfusion lactate clearance for predicting early graft recovery in liver transplant patients: a single centre study

, 2018
BACKGROUND: The role of post-reperfusion lactate clearance in assessing graft function has not yet been investigated. The aim of this study was to examine whether lactate clearance, assessed in the post-reperfusion phase, can predict poor graft function
Sollazzi L., Sacco, Teresa, Sollazzi, Liliana, Perilli, Valter, Aceto P., Ciocchetti, Pierpaolo, Sacco T., Aceto, Paola, Lai, Carlo, Papanice, Domenico, Perilli V.   +10 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Randomized controlled trial of Micro-Mobile Compression® on lactate clearance and subsequent exercise performance in elite male cyclists

, 2013
Iñigo San Millán,1 Kristen Bing,1 Carrie Brill,1 John C Hill,1 Larry E Miller2 1University of Colorado School of Medicine, Aurora, CO, 2Miller Scientific Consulting, Inc, Arden, NC, USA Background: The purpose of this paper was to assess ...
Bing K, Miller LE, Brill C, Hill JC, San Millán I   +4 more
core