Results 121 to 130 of about 60,229 (277)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

The Therapeutic Role of Vasopressin on Improving lactate Clearance During and After Vasogenic Shock: Microcirculation, Is It The Black Box?

Acta Medica Iranica, 2016
Arginine vasopressin as a supplementary vasopressor in septic shock restores vascular tone and mean arterial pressure, meanwhile decreases dose and exposure time to catecholamines.
Elchin Barzegar, Arezoo Ahmadi, Sarah Mousavi, Masoumeh Nouri, Mojtaba Mojtahedzadeh   +4 more
doaj  

Lactate in cardiogenic shock: pathophysiology, prognostic value, and clinical interpretation

Annals of Intensive Care
In cardiogenic shock (CS), blood lactate concentration is routinely used to assess shock severity and guide clinical decisions. However, lactate interpretation is often oversimplified, leading to confusion between disease severity, shock reversibility ...
Bruno Levy, Glenn Hernandez, Hamid Merdji   +2 more
doaj   +1 more source

Lactate clearance, and lactate in predicting mortality in patients with severe trauma

Abstract Purpose: Lactate Clearance (LC) has recently emerged as a therapeutic goal to be achieved in the first hours of septic shock’s resuscitation. In severe trauma patients, there is an urgent need to rapidly assess initial management’s quality and to diagnose occult hypoperfusion at its early stages.
Lotfi Rebai, Melinda Sammary, Olfa Faten, Ichraf Ardhaoui, Sabrine Ben Brahem, Firas Kalai   +5 more
openaire   +1 more source

Effect of lactate clearance rate on survival and functional neurologic recovery rates.

, 2019
The lactate clearance rates were grouped by quartile (Q). Both the rate of survival to discharge and of CPC 1 or 2 at discharge increased with increasing lactate clearance rate (p p = 0.223). CPC, cerebral performance category.
Kyoung Yae Park (6532889), Eui Jung Lee (761495), Su Jin Kim (142497), Sung Woo Lee (747615), Ji Young Lee (235181), Kap Su Han (6532886)   +5 more
core   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

The association of dynamic lactate indices and lactate clearance with mortality in septic patients with acute kidney injury requiring continuous renal replacement therapy

Egyptian Journal of Critical Care Medicine
Background Sepsis is a frequently encountered severe medical condition that impairs multiple bodily systems and results in inadequate tissue perfusion. Aim To evaluate the clinical effectiveness of measuring lactate at various time intervals to predict ...
Sally Salah EL-Dine EL-Soda, Kamel Abd EL-Aziez Mohamed, Ahmad Said Abd-Al Mohsen Ali, Ahmad Hussien Aly Muhammad, Mohamed Gamal Lotfy AL-Ansary   +4 more
doaj   +1 more source

Physiological consequences of the work of breathing and of inspiratory muscle training

, 2009
A reduced blood lactate concentration ([lac-]B) is commonly observed during whole-body exercise following inspiratory muscle training (IMT). However, whether the inspiratory muscles are, in part, the source of these reductions remains unknown ...
Brown, Peter Ian, Brown, P
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source