Results 61 to 70 of about 60,229 (277)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children

, 2020
Objectives: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock. Methods: We performed our test on 50 patients. Out of 50 patients, 28 are male, and 22 are female. Prospectively studied pediatric patients with septic shock were performed.
D M Kamrul Hasan, Shafayat Hossain Evan, Md Rezaul Karim, Xin Yi Men, Zhang Huifeng, Chen Yuan   +5 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

The combination of lactate level, lactate clearance and APACHE II score better predicts short-term outcomes in critically Ill patients: a retrospective cohort study

BMC Anesthesiology, 2022
Background The mortality rate is high in critically ill patients due to the difficulty of diagnosis and treatment. Thus, it is very important to explore the predictive value of different indicators related to prognosis in critically ill patients. Methods
Yongmei Cao, Sijia Yao, Jiawei Shang, Feng Ping, Qin Tan, Zijun Tian, Weifeng Huang, Yingchuan Li   +7 more
doaj   +1 more source

Lactate, lactate clearance and outcome after cardiac arrest : A post-hoc analysis of the TTM-Trial

, 2018
Background: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. Methods: This is a post-hoc analysis of the Target
M. Wanscher, Hassager, C.,, Kuiper, M.,, Vulto, J.,, Kuiper, M., J. Düring, Düring, J., Hassager, C., Pellis, T.,, T. Cronberg, P. Stammet, Nielsen, N.,, Wise, M.,, Kjaergaard, J.,, Friberg, H., Cronberg, T., Wanscher, M., Wanscher, M.,, Cronberg, T.,, A. Åneman, Nielsen, N., J. Kjaergaard, Hovdenes, J.,, Pellis, T., Friberg, H.,, Düring, J.,, M. Wise, Vulto, J., C. Hassager, Kjaergaard, J., Wise, M., Åneman, A., M. Kuiper, J. Vulto, H. Friberg, Dankiewicz, J.,, Stammet, P., T. Pellis, Åneman, A.,, Dankiewicz, J., Hovdenes, J., J. Hovdenes, J. Dankiewicz, Lund University., N. Nielsen, Stammet, P.,   +45 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Role of Serum Lactate Clearance as a Predictor of Mortality and Morbidity in Neonatal Sepsis: A Prospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Neonatal sepsis is a global healthcare concern, which is more prevalent in developing countries. However, surprisingly, biomarkers with good sensitivity and specificity to predict mortality and morbidity are lacking.
Shreya Ray Chaudhuri, Sayan Chatterjee, Subhasish Bhattacharyya, Arijit Banerjee   +3 more
doaj   +1 more source

Failure of lactate clearance predicts the outcome of critically ill septic patients [PDF]

, 2022
Purpose: Early lactate clearance is an important parameter for prognosis assessment and therapy control in sepsis. Patients with a lactate clearance >0% might differ from patients with an inferior clearance in terms of intensive care management and ...
Binneboessel, S., Baldia, P., Duse, D.A., Bruno, R.R., Wernly, B., Jung, C., Mamandipoor, B., Erkens, R., Osmani, V., Kelm, M.   +9 more
core   +1 more source