Results 81 to 90 of about 60,229 (277)

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Effect of blood lactate clearance rate on the prognosis of sepsis patients undergoing continuous renal replacement therapy

Zhongguo linchuang yanjiu
Objective To analyze the blood lactate levels and lactate clearance rate in septic patients undergoing continuous renal replacement therapy (CRRT) with different clinical outcomes, and to explore the value of blood lactate levels and lactate clearance ...
SUN Qin*, YAO Zhiyuan, XIA Wenfang
doaj   +1 more source

Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release

Advanced Materials, EarlyView.
A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet   +5 more
wiley   +1 more source

Lactate Clearance is a Prognostic Factor in Patients on Shock State

Electronic Journal of General Medicine, 2012
L'objectif est de déterminer si la clairance du lactate a une valeur en tant que facteur pronostique de mortalité chez les patients en état de choc, ou non. Une étude longitudinale minutieuse, descriptive, prolective, homodémique chez des patients de plus de 19 ans, excluant les maladies rénales chroniques, l'insuffisance hépatique, les néoplasies et ...
Aurelio López‐Colombo, Álvaro J. Montiel‐Jarquín, Iraí Láscarez-Lagunas, Carlos Sánchez-Gasca, Laura I. Láscarez‐Lagunas, Eugenio García-Cano, Eduardo Gómez-Conde, Mario García‐Carrasco, María Eugenia Guerrero-Fernández   +8 more
openaire   +2 more sources

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Development and validation of a lactate and procalcitonin-based nomogram model for predicting prognosis in ICU sepsis patients

Frontiers in Disaster and Emergency Medicine
ObjectiveA nomogram model for predicting the prognosis of patients with sepsis in the intensive care unit (ICU) was developed based on lactate and procalcitonin (PCT) and externally validated.MethodsFrom the anonymous medical database of the First ...
Kai-Xi Tian, Jie-Xuan Dong, Juan Du, Xu-Bing Huang, Yi Liu   +4 more
doaj   +1 more source

Predictive value of 6 hour lactate clearance rate for mortality rate of septic shock patients with age stratificatio data.xls

, 2022
the Original data of this research,Our data showed that the survivors had higher lactate clearance rate, rather than 10% lactate clearance rate. This result was consistent with the results reported by recent similar studies, showing that >30% lactate ...
Liquan Huang (143599), Chunhua Jin (12913205)   +1 more
core   +1 more source