Results 1 to 10 of about 21,605 (147)

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Frontiers in Pharmacology, 2023
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases ...
Jung Ho Han, Eun-Ji Lee, Wonyoung Park, Ki-Tae Ha, Hwan-Suck Chung, Hwan-Suck Chung   +5 more
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Serum lactate dehydrogenase is associated with impaired lung function: NHANES 2011-2012.

PLoS ONE, 2023
BackgroundSerum lactate dehydrogenase levels reflect disease status in a variety of organs, but its role in indicating pulmonary function is not yet clear.
Sheng Hu, Jiayue Ye, Qiang Guo, Sheng Zou, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Silin Wang, Lang Su, Yiping Wei   +9 more
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Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans. [PDF]

PLoS ONE, 2009
Aggregatibacter actinomycetemcomitans is a Gram-negative opportunistic pathogen and the proposed causative agent of localized aggressive periodontitis. A.
Stacie A Brown, Marvin Whiteley
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Homology modelling and docking analysis of L-lactate dehydrogenase from Streptococcus thermopilus [PDF]

Acta Periodica Technologica, 2016
The aim of this research was to create a three-dimensional model of L-lactate dehydrogenase from the main yoghurt starter culture - Streptococcus thermopilus, to analyse its structural features and investigate substrate binding in the active ...
Vukić Vladimir R., Milanović Spasenija D., Iličić Mirela D., Kanurić Katarina G., Vukić Dajana V.   +4 more
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Clinical observations of Leber hereditary optic neuropathy with and without neurological symptoms [PDF]

Анналы клинической и экспериментальной неврологии, 2022
Three case studies of adults with Leber hereditary optic neuropathy with and without neurological symptoms are presented. An elevated blood lactate level and changes in the activity of the mitochondrial enzymes in peripheral blood lymphocytes were noted.
Sergey V. Kotov, Olga P. Sidorova, Elena V. Borodataya, Irina A. Vasilenko, Alexander V. Borodin   +4 more
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Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma [PDF]

Archive of Oncology, 2008
Background: A rapid increase in the turnover of malignant cells modulates the enzymes level in circulation and may be a prognostic sign of disease progression.
Bogdanović Gordana, Trajković Vesna, Jakimov Dimitar, Mrđanović Jasminka, Nikolić Aleksandra, Đorđević Milan, Turšijan Slavica, Bogdanović Višnja, Ivković-Kapicl Tatjana, Dugandžija Tihomir   +9 more
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Relevance of NADH Dehydrogenase and Alternative Two-Enzyme Systems for Growth of Corynebacterium glutamicum With Glucose, Lactate, and Acetate

Frontiers in Bioengineering and Biotechnology, 2021
The oxidation of NADH with the concomitant reduction of a quinone is a crucial step in the metabolism of respiring cells. In this study, we analyzed the relevance of three different NADH oxidation systems in the actinobacterial model organism ...
Tomoya Maeda, Abigail Koch-Koerfges, Michael Bott   +2 more
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Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Microbiome, 2022
Background Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the ...
Savannah J. Taylor, Maria G. Winter, Caroline C. Gillis, Laice Alves da Silva, Amanda L. Dobbins, Matthew K. Muramatsu, Angel G. Jimenez, Rachael B. Chanin, Luisella Spiga, Ernesto M. Llano, Vivian K. Rojas, Jiwoong Kim, Renato L. Santos, Wenhan Zhu, Sebastian E. Winter   +14 more
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Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma

Tumor Biology, 2017
Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua, Chao Liang, Jundong Zhu, Chenkui Miao, Yajie Yu, Aimin Xu, Jianzhong Zhang, Pu Li, Shuang Li, Meiling Bao, Jie Yang, Chao Qin, Zengjun Wang   +12 more
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The utility of lactate dehydrogenase in the follow up of patients with diffuse large B-cell lymphoma

Revista Brasileira de Hematologia e Hemoterapia, 2013
Background: Serum lactate dehydrogenase is a non-specific marker for lymphoma whose prognostic significance is well established for both indolent and aggressive lymphomas at the time of diagnosis.
Basem Magdy William, Navneeth Rao Bongu, Martin Bast, Robert Gregory Bociek, Philip Jay Bierman, Julie Marie Vose, James Olen Armitage   +6 more
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