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Human D‐Lactate Dehydrogenase Deficiency: A Case Report in a Young Boy [PDF]

JIMD Reports
D‐lactate is an isomeric form of lactate, which is almost undetectable in the circulation in individuals with normal lactate metabolism. Patients diagnosed with the disease human D‐lactate dehydrogenase deficiency present with elevated plasma D‐lactate ...
T. B. Sloth, M. C. Ørngreen, J. Ek, I. Bache, F. Wibrand, A. M. Lund   +5 more
doaj   +2 more sources

Utilizing the Lactate Dehydrogenase-to-Albumin Ratio for Survival Prediction in Patients with Neuroblastoma [PDF]

Children
Purpose: This study aimed to investigate the association between lactate dehydrogenase-to-albumin ratio (LAR) and the clinical characteristics and overall survival (OS) of patients with neuroblastoma (NB).
Suwen Li, Yue Ma, Shan Wang
doaj   +2 more sources

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Frontiers in Pharmacology, 2023
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases ...
Jung Ho Han, Eun-Ji Lee, Wonyoung Park, Ki-Tae Ha, Hwan-Suck Chung, Hwan-Suck Chung   +5 more
doaj   +1 more source

Shotgun metagenomic mining reveals a new FAD-dependent D-lactate dehydrogenase in an isopod gut microbiome. [PDF]

Appl Environ Microbiol
Coelho C, Taborda A, Lorena C, Frazão T, Veríssimo A, Borges PT, Brissos V, Tiago I, Martins LO.   +8 more
europepmc   +2 more sources

Serum lactate dehydrogenase is associated with impaired lung function: NHANES 2011-2012.

PLoS ONE, 2023
BackgroundSerum lactate dehydrogenase levels reflect disease status in a variety of organs, but its role in indicating pulmonary function is not yet clear.
Sheng Hu, Jiayue Ye, Qiang Guo, Sheng Zou, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Silin Wang, Lang Su, Yiping Wei   +9 more
doaj   +1 more source

Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans. [PDF]

PLoS ONE, 2009
Aggregatibacter actinomycetemcomitans is a Gram-negative opportunistic pathogen and the proposed causative agent of localized aggressive periodontitis. A.
Stacie A Brown, Marvin Whiteley
doaj   +1 more source

Homology modelling and docking analysis of L-lactate dehydrogenase from Streptococcus thermopilus [PDF]

Acta Periodica Technologica, 2016
The aim of this research was to create a three-dimensional model of L-lactate dehydrogenase from the main yoghurt starter culture - Streptococcus thermopilus, to analyse its structural features and investigate substrate binding in the active ...
Vukić Vladimir R., Milanović Spasenija D., Iličić Mirela D., Kanurić Katarina G., Vukić Dajana V.   +4 more
doaj   +1 more source

Clinical observations of Leber hereditary optic neuropathy with and without neurological symptoms [PDF]

Анналы клинической и экспериментальной неврологии, 2022
Three case studies of adults with Leber hereditary optic neuropathy with and without neurological symptoms are presented. An elevated blood lactate level and changes in the activity of the mitochondrial enzymes in peripheral blood lymphocytes were noted.
Sergey V. Kotov, Olga P. Sidorova, Elena V. Borodataya, Irina A. Vasilenko, Alexander V. Borodin   +4 more
doaj   +1 more source

Relevance of NADH Dehydrogenase and Alternative Two-Enzyme Systems for Growth of Corynebacterium glutamicum With Glucose, Lactate, and Acetate

Frontiers in Bioengineering and Biotechnology, 2021
The oxidation of NADH with the concomitant reduction of a quinone is a crucial step in the metabolism of respiring cells. In this study, we analyzed the relevance of three different NADH oxidation systems in the actinobacterial model organism ...
Tomoya Maeda, Abigail Koch-Koerfges, Michael Bott   +2 more
doaj   +1 more source

Activity of lactate dehydrogenase and superoxide dismutase in the circulation of patients with breast carcinoma [PDF]

Archive of Oncology, 2008
Background: A rapid increase in the turnover of malignant cells modulates the enzymes level in circulation and may be a prognostic sign of disease progression.
Bogdanović Gordana, Trajković Vesna, Jakimov Dimitar, Mrđanović Jasminka, Nikolić Aleksandra, Đorđević Milan, Turšijan Slavica, Bogdanović Višnja, Ivković-Kapicl Tatjana, Dugandžija Tihomir   +9 more
doaj   +1 more source