Results 1 to 10 of about 801,950 (399)

Human D‐Lactate Dehydrogenase Deficiency: A Case Report in a Young Boy [PDF]

JIMD Reports
D‐lactate is an isomeric form of lactate, which is almost undetectable in the circulation in individuals with normal lactate metabolism. Patients diagnosed with the disease human D‐lactate dehydrogenase deficiency present with elevated plasma D‐lactate ...
T. B. Sloth, M. C. Ørngreen, J. Ek, I. Bache, F. Wibrand, A. M. Lund   +5 more
doaj   +2 more sources

Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma

Tumor Biology, 2017
Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua, Chao Liang, Jundong Zhu, Chenkui Miao, Yajie Yu, Aimin Xu, Jianzhong Zhang, Pu Li, Shuang Li, Meiling Bao, Jie Yang, Chao Qin, Zengjun Wang   +12 more
doaj   +2 more sources

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Frontiers in Pharmacology, 2023
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases ...
Jung Ho Han, Eun-Ji Lee, Wonyoung Park, Ki-Tae Ha, Hwan-Suck Chung, Hwan-Suck Chung   +5 more
doaj   +1 more source

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Science, 2023
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover.
Kevin G. Hicks, A. Cluntun, H. Schubert, S. Hackett, J. A. Berg, P. Leonard, Mariana A. Ajalla Aleixo, Youjia Zhou, Alex J. Bott, S. Salvatore, Fei Chang, Aubrie Blevins, Paige Barta, Samantha Tilley, Aaron Leifer, Andrea L. Guzman, Ajak Arok, S. Fogarty, Jacob M. Winter, H. Ahn, Karen N. Allen, Samuel Block, I. Cardoso, Jianping Ding, I. Dreveny, William C. Gasper, Quinn Ho, A. Matsuura, M. Palladino, S. Prajapati, P. Sun, K. Tittmann, D. Tolan, J. Unterlass, A. Vandemark, M. V. Vander Heiden, Bradley A. Webb, C. Yun, P. Zhao, Bei Wang, F. Schopfer, C. Hill, M. Nonato, F. Muller, J. Cox, J. Rutter   +45 more
semanticscholar   +1 more source

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

Nature Communications, 2023
The role of glycolysis in depression is unclear. Here the authors report a glycolytic deficit under social stress and demonstrate that astrocytic LDHA affects neuronal excitability and depressive-like behaviours via lactate homeostasis in mice ...
Shan Yao, Min-Dong Xu, Ying Wang, Shen-Ting Zhao, Jin Wang, Guiju Chen, Wenbing Chen, Jian Liu, Guo-bin Huang, W. Sun, Yanyan Zhang, Huan-Li Hou, Lei Li, Xiang-Dong Sun   +13 more
semanticscholar   +1 more source

The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients

Inflammation, 2022
Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of anaerobic glycolysis with end product of lactate from glucose. The lactate formation is crucial in the metabolism of glucose when oxygen is in inadequate supply.
G. Gupta
semanticscholar   +1 more source

Mutual regulation of lactate dehydrogenase and redox robustness

Frontiers in Physiology, 2022
The nature of redox is electron transfer; in this way, energy metabolism brings redox stress. Lactate production is associated with NAD regeneration, which is now recognized to play a role in maintaining redox homeostasis.
Yijun Lin, Yan Wang, Pei-feng Li
semanticscholar   +1 more source

Serum lactate dehydrogenase is associated with impaired lung function: NHANES 2011-2012.

PLoS ONE, 2023
BackgroundSerum lactate dehydrogenase levels reflect disease status in a variety of organs, but its role in indicating pulmonary function is not yet clear.
Sheng Hu, Jiayue Ye, Qiang Guo, Sheng Zou, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Silin Wang, Lang Su, Yiping Wei   +9 more
doaj   +1 more source

Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans. [PDF]

PLoS ONE, 2009
Aggregatibacter actinomycetemcomitans is a Gram-negative opportunistic pathogen and the proposed causative agent of localized aggressive periodontitis. A.
Stacie A Brown, Marvin Whiteley
doaj   +1 more source

Homology modelling and docking analysis of L-lactate dehydrogenase from Streptococcus thermopilus [PDF]

Acta Periodica Technologica, 2016
The aim of this research was to create a three-dimensional model of L-lactate dehydrogenase from the main yoghurt starter culture - Streptococcus thermopilus, to analyse its structural features and investigate substrate binding in the active ...
Vukić Vladimir R., Milanović Spasenija D., Iličić Mirela D., Kanurić Katarina G., Vukić Dajana V.   +4 more
doaj   +1 more source