Results 41 to 50 of about 801,950 (399)

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +5 more sources

The Lactate Dehydrogenases of Hemopoietic Cells [PDF]

Blood, 1966
Abstract In summary we have demonstrated that hemopoietic stem cells of man contain all five isoenzymes, and not a single pure type. Our data and the results of others obtained from fetal tissue also indicate that embryonic LDH of man exists as multiple forms.
Spencer Hh, Spencer Hh, W. H. Starkweather, W. H. Starkweather, H. K. Schoch, H. K. Schoch   +5 more
openaire   +3 more sources

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

Cancers, 2019
Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients. We have recently reported that programmed cell death protein-1 (PD-1) ligand (PD-L1) expression is regulated by lactate present at ...
S. Daneshmandi, B. Wegiel, P. Seth
semanticscholar   +1 more source

Characterization of Rabbit Lactate Dehydrogenase-M and Lactate Dehydrogenase-H cDNAs

Journal of Biological Chemistry, 1989
Two cDNA clones were isolated, one corresponding to the mRNA coding for lactate dehydrogenase-M (LDH-M), the other to the mRNA coding for lactate dehydrogenase-H (LDH-H). The cDNA inserts consist of the entire open reading frame for LDH-M and a partial sequence, from amino acid 117 to 332, for LDH-H. Using these two clones as probes we demonstrate that:
M Renaud, M Briand, C Sass, S Benslimane, Yves Briand   +4 more
openaire   +3 more sources

Electron transport phosphorylation in rumen butyrivibrios: unprecedented ATP yield for glucose fermentation to butyrate. [PDF]

, 2015
From a genomic analysis of rumen butyrivibrios (Butyrivibrio and Pseudobutyrivibrio sp.), we have re-evaluated the contribution of electron transport phosphorylation (ETP) to ATP formation in this group.
Firkins, Jeffrey L, Hackmann, Timothy J
core   +2 more sources

Relative catalytic efficiencies and transcript levels of three d‐ and two l‐lactate dehydrogenases for optically pure d‐lactate production in Sporolactobacillus inulinus

MicrobiologyOpen, 2019
As the optical purity of the lactate monomer is pivotal for polymerization, the production of optically pure d‐lactate is of significant importance. Sporolactobacillus inulinus YBS1‐5 is a superior optically pure d‐lactate‐producing bacterium.
Bin Wu, Qi Yu, Shan Zheng, Marcelo Monteiro Pedroso, Luke W. Guddat, Bingfang He, Gerhard Schenk   +6 more
doaj   +1 more source

Identification of human D lactate dehydrogenase deficiency

Nature Communications, 2019
Phenotypic and biochemical categorization of humans with detrimental variants can provide valuable information on gene function. We illustrate this with the identification of two different homozygous variants resulting in enzymatic loss-of-function in ...
G. Monroe, A. V. van Eerde, F. Tessadori, K. Duran, Sanne M. C. Savelberg, J. C. van Alfen, P. Terhal, Saskia N. van der Crabben, K. Lichtenbelt, S. Fuchs, J. Gerrits, M. V. van Roosmalen, K. V. van Gassen, M. van Aalderen, B. Koot, M. Oostendorp, M. Durán, G. Visser, T. D. de Koning, F. Calì, P. Bosco, K. Geleijns, M. G. M. de Sain-van der Velden, N. Knoers, J. Bakkers, N. Verhoeven-Duif, G. van Haaften, J. Jans   +27 more
semanticscholar   +1 more source

Stabilization of lactate dehydrogenase [PDF]

, 1972
Addition of substances such as dimethylsulfoxide, glycerol, and gelatin to aqueous solutions of lactate dehydrogenase maintains enzymes in stable and fully active form when stored at 2 - 6 ...
Friedman, O. M.
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

l-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous l-lactate dehydrogenase

Scientific Reports, 2023
l-Lactate is a major waste compound in cultured animal cells. To develop a sustainable animal cell culture system, we aimed to study the consumption of l-lactate using a photosynthetic microorganism.
Yuichi Kato, Kosuke Inabe, Yuji Haraguchi, Tatsuya Shimizu, Akihiko Kondo, Tomohisa Hasunuma   +5 more
doaj   +1 more source