Results 141 to 150 of about 1,126 (255)

The effect of post-exercise rating time on session RPE

, 2012
This study evaluated the effect of post-exercise time on session rating of perceived exertion (sRPE) following steady-state and interval exercise bouts on a cycle ergometer.
Christen, Joshua D.
core  

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Ames Laboratory, Iowa State University (IS) Report IS-445

, 1962
From abstract: "Lactates of all the rare earths except lanthanum, cerium, and praseodymium were prepared and studied. In the case of lanthanum, cerium, and praseodymium the lactates are apparently so soluble that they cannot be crystallized directly from
Powell, J. E., Farrell, J. L.
core  

Lactate Values and Mortality in Patients With Cardiogenic Shock: Insights From the Altshock-2 Registry

Objectives: We aimed to evaluate the prognostic role of baseline and 24-hour plasma lactates in patients with cardiogenic shock (CS). Design: Multicenter, observational, prospective Altshock-2 Registry (NCT04295252) enrolling patients with CS since March
Frea, Simone, De Ferrari, Gaetano Maria, D'Ettore, Nicoletta, Pappalardo, Federico, Valente, Serafina, Morici, Nuccia, Pagnesi, Matteo, Potena, Luciano, Rota, Matteo, Oliva, Fabrizio, Viola, Giovanna, Camporotondo, Rita, Riccardi, Mauro, Bertaina, Maurizio, Bertoldi, Letizia Fausta, Marini, Marco, Tavazzi, Guido, Briani, Martina, Cardinale, Astrid, Sacco, Alice, Metra, Marco   +20 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

L'intérêt du dosage des lactates dans la douleur abdominale aux urgences

, 2018
Introduction : La douleur abdominale aiguë non traumatique peut témoigner d’une pathologie bénigne ou grave mettant en jeu le pronostic vital. De nombreux marqueurs biologiques ont été évalués mais n’ont pas démontré à eux seuls de véritable intérêt en ...
Janelle, Marine
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Blood lactates as prognostic index for surgical resolution of right displaced abomasum complicated by torsion in dairy cow

, 2015
Quarantanove bovine da latte affette da dislocazione abomasale a destra complicata da torsione, sono state arruolate nello studio. Prima di procedere con l’intervento chirurgico, gli animali sono stati sottoposti a prelievo di sangue onde rilevare la ...
Cavirani, Pietro
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source