Results 41 to 50 of about 77,943 (339)

Intra-Abdominal Metabolism and Blood Flow During Abdominal Hypertension and ndash; A Porcine Pilot Study Under Intravenous Anaesthesia

Archives of Clinical and Experimental Surgery, 2013
Objective: To study the splanchnic metabolism and intestinal circulation in a porcine model with increased abdominal pressure. Methods: In an experimental porcine study, performed under intravenous anaesthesia, five animals were subjected to gradually ...
Per Skoog, Tal M. Horer, Goran and Aring;gren, Kjell Jansson, Lars Norgren   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Association of Postoperative Serum Lactate Levels with Acute Kidney Injury in Mexican Patients Undergoing Cardiac Surgery

Clinics and Practice
Acute kidney injury (AKI) is a highly prevalent and a critical complication of cardiac surgery (CS). Serum lactate (sLac) levels have consistently shown an association with morbimortality after CS. We performed a cross-sectional study including 264 adult
Héctor-Enrique Flores-Salinas, Anahí de Jesús Zambada-Gamboa, Texali-Candelaria Garcia-Garduño, Guillermo Rodríguez-Zavala, Yeminia Valle, Juan-Carlos Chávez-Herrera, Porfirio-Eduardo Martinez-Gutierrez, Arturo Godinez-Flores, Salvador Jiménez-Limón, Jorge-Ramón Padilla-Gutiérrez   +9 more
doaj   +1 more source

Normal saline versus balanced crystalloids in patients with prerenal acute kidney injury and pre-existing chronic kidney disease

Romanian Journal of Internal Medicine, 2023
Normal saline (N/S) and Ringer’s-Lactate (L/R), are administered in everyday clinical practice. Despite that, N/S increases the risk of sodium overload and hyperchloremic metabolic acidosis.
Papasotiriou Marios, Mpratsiakou Adamantia, Georgopoulou Georgia, Ntrinias Theodoros, Balta Lamprini, Pavlakou Paraskevi, Goumenos Dimitrios S., Papachristou Evangelos   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Enantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes

Nature Communications, 2023
Organosilanes possessing an enantioenriched stereogenic silicon center are important in many branches of chemistry, yet they remain challenging to synthesize in a practical and scalable way. Here we report a dynamic kinetic silyletherification process of
Tianbao Hu, Chen Zhao, Yan Zhang, Yuzhong Kuang, Lu Gao, Wanshu Wang, Zhishan Su, Zhenlei Song   +7 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Correlation between Persistent Serum Lactate Elevation and Brain Magnetic Resonance Imaging Abnormalities in Children with Status Epilepticus [PDF]

Annals of Child Neurology
Purpose This study was conducted to evaluate the correlation between persistent serum lactate elevation and brain magnetic resonance imaging (MRI) in children with status epilepticus (SE).
Prastiya Indra Gunawan, Riza Noviandi, Sunny Mariana Samosir   +2 more
doaj   +1 more source

“Lactate Shift,” Rather Than “Lactate Clearance,” for Serial Blood Lactate Monitoring?

Critical Care Medicine, 2015
To the Editor:We read with interest the letter to the editor by Dr. Vincent (1) citing our work (2) on blood lactate in patients with sepsis admitted to intensive care, and we broadly agree with the points he raised.
Walker, Craig, Griffith, David, Gray, Alasdair, Datta, Deepankar, Hay, Alastair   +4 more
openaire   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source