Results 51 to 60 of about 77,943 (339)

Semaglutide and High-Intensity Interval Exercise Attenuate Cognitive Impairment in Type 2 Diabetic Mice via BDNF Modulation

open access: yesBrain Sciences
Background/Objectives: Diabetes frequently leads to cognitive impairment, encompassing issues with memory and executive function, as well as depression and anxiety.
Sijie Lai   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Lactation Curves for First Lactation Egyptian Buffalo

open access: yesJournal of Dairy Science, 1994
First lactation records of 1538 buffalo maintained at the Animal Production Research Institute farms in 1967 to 1990 were used to determine lactation curves for three lactation lengths: > 28 and < 150 d, > 149 d, and > or = 308 d, as well as all records. Daily milk yields were summed by 14-d intervals for analyses.
G H, Metry   +3 more
openaire   +2 more sources

Informetrics on accidents and trauma [PDF]

open access: yes, 1998
MEDLINE database has been analysed for 1995-97 on index Accidents and Trauma. Publications output has been classified year-wise country-wise, journal-wise and other fine structure characteristics have been found.
Kadam, S. N., Kalyane, V. L.
core  

Polishing of synthetic electroplating wastewater in microcosm upflow constructed wetlands: Effect of operating conditions [PDF]

open access: yes, 2014
International audienceThis paper addresses the issue of polishing electroplating wastewater in subsurface vertical flow constructed wetland. Electroplating wastewater treatment or polishing in constructed wetlands (CWs) was studied to a very limited ...
Faure, Olivier   +3 more
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

L'économie de mouvement en course à pied : comparaison entre mesures objectives et évaluations subjectives par l'entraineur spécialisé [PDF]

open access: yes, 2014
L'économie de mouvement en course à pied est un paramètre essentiel pour la performance et de nouvelles méthodes d'entrainement essaient aujourd'hui de le cibler.
BACHER, S.
core  

Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype [PDF]

open access: yes, 2013
To examine whether polymorphic mtDNA mutations that do not induce significant respiration defects regulate phenotypes of tumor cells, we used mouse transmitochondrial tumor cells (cybrids) with nuclear DNA from C57BL/6 (B6) strain and mtDNA from ...
Hayashi Jun-Ichi   +11 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic

open access: yesJournal of Veterinary Internal Medicine
Background Colic‐related obstructions can reduced intestinal mucosa function and cause dysbiosis in horses, but it is unclear how defense barrier and secretory immunoglobulin A (SIgA) secretion is disrupted. Objectives The aim of the study is to evaluate
Agnieszka Żak‐Bochenek   +6 more
doaj   +1 more source

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