Results 81 to 90 of about 320,077 (372)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Identifying high-risk undifferentiated emergency department patients with hyperlactatemia: Predictors of 30-day in-hospital mortality

Turkish Journal of Emergency Medicine
BACKGROUND: Hyperlactatemia has been recognized as a significant prognostic indicator in critically ill patients. Nonetheless, there remains a gap in understanding the specific risk factors contributing to increased mortality among undifferentiated ...
Ayşen Aydın Kaçar, Ersin Aksay, Başak Bayram, Emre Kıran, Bahar Elif Güldalı   +4 more
doaj   +1 more source

Mutual-Information Based Optimal Experimental Design for Hyperpolarized $^{13}$C-Pyruvate MRI [PDF]

arXiv, 2022
A key parameter of interest recovered from hyperpolarized (HP) MRI measurements is the apparent pyruvate-to-lactate exchange rate, $k_{PL}$, for measuring tumor metabolism. This manuscript presents an information-theory-based optimal experimental design (OED) approach that minimizes the uncertainty in the rate parameter, $k_{PL}$, recovered from HP-MRI
arxiv  

Nutrition and lactation [PDF]

Postgraduate Medical Journal, 1979
Summary Recommended dietary allowances for women during pregnancy are discussed in the light of actual intakes both in the developing and industrialized countries. The difference between total energy intakes in the industrialized countries (around 2900 kcal) and in the developing countries (around 1600 kcal) is emphasized.
openaire   +3 more sources

Conformational change of an amylose derivative in chiral solvents: amylose tris(n-butylcarbamate) in ethyl lactates

, 2012
The z-average radius of gyration, the particle scattering function and the intrinsic viscosity have been determined for amylose tris(n-butylcarbamate) (ATBC) in D-, DL- and L-ethyl lactates, all at 25 °C, by light and small-angle X-ray scattering and ...
Shota Arakawa, K. Terao, S. Kitamura, Takahiro Sato   +3 more
semanticscholar   +1 more source

Variations in capillary and serum lactates levels based on different etiologies of septic patients in the emergency department

Frontiers in Medicine
IntroductionSepsis is a life-threating and time-depending condition. This study examined the association between sepsis etiology and variations in capillary and serum lactate levels, neutrophil-to-lymphocyte ratio, and diastolic shock index in emergency ...
Matteo Guarino, Matteo Guarino, Benedetta Perna, Giacomo Maroncelli, Paolo Baldin, Chiara Donati, Francesco Luppi, Alice Eleonora Cesaro, Chiara Pesci, Anna Costanzini, Martina Maritati, Paolo Clavenzani, Carlo Contini, Roberto De Giorgio, Michele Domenico Spampinato, Michele Domenico Spampinato   +15 more
doaj   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Blood lactate concentration prediction in critical care patients: handling missing values [PDF]

arXiv, 2019
Blood lactate concentration is a strong indicator of mortality risk in critically ill patients. While frequent lactate measurements are necessary to assess patient's health state, the measurement is an invasive procedure that can increase risk of hospital-acquired infections.
arxiv  

(2-Hydroxyethyl)ammonium Lactates—Highly Biodegradable and Essentially Non-Toxic Ionic Liquids

, 2011
(2-Hydroxyethyl)ammonium lactates have been prepared by reactions of the corresponding (2-hydroxyethyl) amines with lactic acid and characterized by their 1H NMR, IR, and mass spectra.
S. Pavlovica, A. Zicmanis, E. Gzibovska, M. Kļaviņš, P. Mekšs   +4 more
semanticscholar   +1 more source

Antimicrobial Effects of Lactates: A Review.

Journal of Food Protection, 1994
Sodium lactate is used as humectant and flavor enhancer in meat and poultry products, and there is growing evidence of antimicrobial properties of the salt.
L. Shelef
semanticscholar   +1 more source