Results 111 to 120 of about 12,286,981 (307)

Comparative Effects of Dietary Supplementations with Sodium Butyrate, Medium-chain Fatty Acids, and n-3 Polyunsaturated Fatty Acids in Late Pregnancy and Lactation on the Reproductive Performance of Sows and Growth Performance of Suckling Piglets.

Journal of Animal Science, 2019
This study was conducted to compare the effects of adding sodium butyrate (SB), medium-chain fatty acids (MCFA), or n-3 polyunsaturated fatty acids (n-3 PUFA) to the diet of sows during late gestation and lactation on the reproductive performance of sows
Jinchao Chen, Qingqing Xu, Yunxia Li, Zhi-Ru Tang, Wei-Zhong Sun, Xiangxin Zhang, Jia-Jing Sun, Zhi-Hong Sun   +7 more
semanticscholar   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Oxidative stress status and reproductive performance of sows during gestation and lactation under different thermal environments

Asian-Australasian Journal of Animal Sciences, 2019
Objective Two experiments were conducted using 28 healthy multiparous sows to evaluate the oxidative stress status and reproductive performance of sows during gestation and lactation under different thermal environments. Methods Fourteen multiparous sows
Yan Zhao, S. Kim
semanticscholar   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Effects of α-Ketoglutarate Peripartum Supplementation on Reproductive, Lactational, Productive and Immunological Outcomes in Dairy Cows

Animals
In dairy cow, the peripartum metabolic stage is critical as may affect post-partum metabolic and reproductive recovery, colostrum quality, and overall reproductive fitness. This study aimed to evaluate the effects of varying doses of α-ketoglutarate (AKG)
Peng Wang, Xin Hu, Xiang’ao Shan, Jiarui Gao, Fei Guo, Bingyuan Wang, Guoshi Liu   +6 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Effects of Supplementing Rumen-Protected Glutathione on Lactation Performance, Nutrients, Oxidative Stress, Inflammation, and Health in Dairy Cows During the Transition Period

Veterinary Sciences
Glutathione (GSH), widely present in plant and animal cells and crucial for combating oxidative stress and inflammation, has not been evaluated in dairy cows.
Yu Hao, Xuejie Jiang, Rui Sun, Yunlong Bai, Chuang Xu, Yuxi Song, Cheng Xia   +6 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Effects of postbiotic products from Saccharomyces cerevisiae fermentation on lactation performance, antioxidant capacity, and blood immunity in transition dairy cows

Journal of Dairy Science
: This study aimed to evaluate the effects of dietary supplementation with different types of Saccharomyces cerevisiae fermentation products (SCFP) on lactational performance, metabolism, acute phase protein response, and antioxidant capacity in dairy ...
Dongwen Dai, Fanlin Kong, Haoqi Han, Weina Shi, Han Song, Ilkyu Yoon, Shuo Wang, Xiaojing Liu, Na Lu, Wei Wang, Shengli Li   +10 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source