Results 131 to 140 of about 215,605 (258)

Euglycemic Ketoacidosis and Lactic Acidosis Associated With Metformin Toxicity.

In patients with diabetes, diabetic ketoacidosis (DKA) is a well-documented potential complication, usually presenting with hyperglycemia, anion gap acidosis, and positive ketones.
Rajagopalan, Kanya, Tien, Jung-Jung, Al-Moussally, Feras, Crouse, Roger, Boterosuarez, Carlos   +4 more
core   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, Volume 20, Issue 11, Page 2656-2673, November 2026.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Lactic acidosis in diabetic patients: diagnosis and treatment

Lactic acidosis is a nonspecific syndrome that develops in a number of severe diseases, when prerequisites are created for increased formation and accumulation of lactic acid in the blood and peripheral tissues.
Boris Mankovsky, Oleksandr Halushko, Mykola Gumenyuk   +2 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 11, Page 2354-2370, November 2026.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2409-2419, November 2026.
ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco, Aaron Williams, Claudia Soler‐Alfonso, Emily Waskow, Elizabeth Mizerik, Fernando Scaglia, Chaya N. Murali   +6 more
wiley   +1 more source

Glycolysis and Bone Formation: From Pathological Mechanisms to Regulatory Strategies

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Bone homeostasis is maintained by the balance between osteoblast‐mediated bone formation and osteoclast‐induced bone resorption, and reduced osteoblastic activity contributes to osteoporosis (OP) and other bone disorders. Energy metabolism, especially glycolysis, has emerged as a critical regulator of osteoblast function and bone formation ...
Suzhen Chao, Yili Zhou, Junjie Xia, Nuoping Wu, Shuyu Zhan, Liang Zhang, Bo Liu   +6 more
wiley   +1 more source

Lactic Acidosis Secondary to Metformin in a Patient Presenting with Acute Renal Failure due to Diarrhea: Case Report

Turkish Journal of Nephrology, 2019
Metformin is a biguanide used in the treatment of type 2 diabetic patients with normal renal function. Lactic acidosis is the most serious side effect of metformin. Renal failure is the most common cause of reduced lactate excretion.
Mustafa YAPRAK, Mehmet Nuri TURAN, Aygül ÇELTİK, Meltem SEZİŞ DEMİRCİ, Erhan TATAR, Arzu Nazlı ZEKA, Hüsnü PULLUKÇU, Mehmet ÖZKAHYA   +7 more
doaj  

Possible cannabinoid-induced lactic acidosis requiring emergent dialysis

SAGE Open Medical Case Reports
Lactic acidosis is a common finding in the intensive care unit and is associated with increased mortality. We present the case of a 42-year-old male with alcohol use disorder and cirrhosis who developed sudden onset shortness of breath while smoking ...
Marcus H Cummins, Brandon J Croft
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis in a Patient With Alcohol‐Associated Liver Disease: A Case Report Highlighting Diagnostic Challenges

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome with nonspecific clinical manifestations that can mimic common conditions in patients with alcohol dependence. Early clinical suspicion and rapid initiation of treatment are essential to prevent fatal outcomes.
Adalis Rivera, Hakan R. Toka, Yasser Samra, Aleena Khan, Kathryn Bower   +4 more
wiley   +1 more source

Immune Checkpoint Inhibitor‐Induced Diabetic Ketoacidosis in a Patient With Pre‐Existing Type 2 Diabetes: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Immune checkpoint inhibitors (ICIs) may cause rare life‐threatening ICI‐associated diabetes mellitus. We report a 60‐year‐old Chinese male with pre‐existing type 2 diabetes who developed toripalimab‐induced diabetic ketoacidosis after 3 treatment cycles. He also had toripalimab‐related hyperthyroidism.
Lingfen Zeng, Jieming Sun
wiley   +1 more source