Results 141 to 150 of about 41,340 (258)

백혈병으로 전환된 림프종 환자에서 발생한 유산산증(Lactic Acidosis)

, 1999
Occurence of lactic acidosis with adequate tissue oxygenation(type B lactic acidosis) has been described in association with leukemia, lymphoma, small cell carcinoma and breast cancer. However, no such case has been reported in Korea.
Shin, GT, Kim, DH, Hyun, BH, Kim, HS, Ahn, SK, Seo, YJ, Kim, MS, Ma, KA, Kim, SJ, Chung, HJ   +9 more
core  

Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance

The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.
Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley   +1 more source

Cellular Responses to Lactic Acidosis in Human Cancers

, 2010
The physiology of the tumor microenvironment is characterized by lower oxygen (hypoxia), higher lactate, extracellular acidosis and glucose starvation.
Chen, Julia Ling-Yu
core  

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes, Michiel J. Bakkum, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +4 more
wiley   +1 more source

T Cell Dysfunction in the Acidic Tumor Microenvironment

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Solid tumors are characterized by profound metabolic and vascular abnormalities that generate a hostile tumor microenvironment (TME) marked by extracellular acidosis, hypoxia, and nutrient deprivation. While the consequences of these conditions for cancer cell behavior have been extensively studied, their impact on anti‐tumor immune responses ...
F. B. Christiansen, E. S. Novella, A. V. Lindemann, J. F. H. Cordes, S. F. Pedersen   +4 more
wiley   +1 more source

Severe Metformin-Associated Lactic Acidosis-A Case Report. [PDF]

Clin Case Rep
Artinyan E, Nikolov G, Valcheva E, Baniya P, Sritharan D, Khan A, Vaysilova M, Dimov N.   +7 more
europepmc   +1 more source

Hypoxic‐hypocapnic red blood cells in PAGGSM additive solution before and after gamma irradiation show improved metabolism

Vox Sanguinis, Volume 121, Issue 6, Page 801-808, June 2026.
Abstract Background and Objectives Hypoxic/hypocapnic (HH) treatment and storage conditions have been shown to reduce oxidative stress and improve red blood cell (RBC) quality. This study aimed to validate a good manufacturing practice HH RBC product for obtaining the licence for routine use in patients, by comparison with normoxic RBCs both without ...
Soroth Chey, Jacqueline Maier, Samuel Sowemimo‐Coker, Reinhard Henschler   +3 more
wiley   +1 more source

Neonatal Lactic Acidosis Associated With Antiretroviral Exposure: A Case Report. [PDF]

Cureus
Mercado J, Rivera L, Droz López A, Poventud Y, Andino-Colón C.   +4 more
europepmc   +1 more source

Metformin-Associated Lactic Acidosis [PDF]

Endocrinology and Metabolism, 2015
Sunghwan Suh
doaj   +1 more source