Results 41 to 50 of about 65,237 (244)

Risk Factors for Symptomatic Hyperlactatemia and Lactic Acidosis Among Combination Antiretroviral Therapy-Treated Adults in Botswana: Results from a Clinical Trial [PDF]

, 2014
Nucleoside analogue reverse transcriptase inhibitors are an integral component of combination antiretroviral treatment regimens. However, their ability to inhibit polymerase-γ has been associated with several mitochondrial toxicities, including ...
Bussmann, Hermann, D, Richard T., De Gruttola, Victor Gerard, Eden, Svetlana K., Essex, Myron Elmer, Hendrickson, Sher L., Marlink, Richard G., Novitsky, Vladimir A., O, Stephen J., Samuels, David C., Shepherd, Bryan E., Wester, C William, Winkler, Cheryl A.   +12 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Warburg′s effect on solid tumors

Saudi Journal of Kidney Diseases and Transplantation, 2014
Lactic acidosis is the result of imbalance between the systemic formation of lactate and its hepatic metabolism. In cancer patients, lactic acidosis is mainly associated with hematologic malignancies (leukemia and lymphomas) and the mechanism is known as
Talal El Imad, Lara El Khoury, Abdallah Sassine Geara   +2 more
doaj   +1 more source

Serum lactate as a prognostic factor in coronary artery bypass graft operation by on pump method [PDF]

, 2013
Background: Lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. This investigation was designed to integrate basic concepts about lactate acidosis with a clinically ...
Alereza, H., Alijanpour, E., Banihashem, N., Jabbari, A., Rabiee, S.M., Vafaey, H.R.   +5 more
core   +1 more source

Implications of moderate altitude training for sea level endurance in elite distance runners [PDF]

, 1998
Elite distance runners participated in one of two studies designed to investigate the e ects of mod- erate altitude training (inspiratory partial pressure of oxygen »115±125 mmHg) on submaximal, maximal and supramaximal exercise performance following
Bailey, DM, Castell, L, Davies, B, Gandy, G, Newsholme, E, Romer, L   +5 more
core   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

EFFECTS ON IONIZED CALCIUM OF A CORRECTION OF ACIDOSIS WITH ALKALINIZING AGENTS [PDF]

, 2017
SUMMARY The effects on the ionized calcium concentration of a correction of various forms of acidosis with sodium bicarbonate or (tris-hydroxymethyl)aminomethane (THAM) were investigated in vitro in human plasma.
SCHAER, H.
core  

Hemodialysis for lactic acidosis

Indian Journal of Critical Care Medicine, 2017
Lactic acidosis (Type A) is common in critically ill patients and usually treated by correcting the underlying etiology. We present the case of a young female who presented with life-threatening lactic acidosis secondary to hematological malignancy. Timely initiation of hemodialysis was lifesaving. The case highlights the importance of considering Type
Karthiraj, N., Ramakrishnan, Nagarajan, Mani, Ashwin K.   +2 more
openaire   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Type B Lactic Acidosis Secondary to Malignancy: Case Report, Review of Published Cases, Insights into Pathogenesis, and Prospects for Therapy

The Scientific World Journal, 2011
Most of the information about type B lactic acidosis associated with cancer is derived from case reports and there are no randomized controlled trials to compare different therapeutic modalities.
Juan P. Ruiz, Ashok Singh, Peter Hart
doaj   +1 more source