Results 51 to 60 of about 215,605 (258)

The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis

Journal of Biomedical Science
Background During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion.
Philipp Terpe, Stefanie Ruhs, Virginie Dubourg, Michael Bucher, Michael Gekle   +4 more
doaj   +1 more source

Severe Lactic Acidosis Associated with Burkitt's Lymphoma

, 2015
Lactic acidosis is a metabolic acidosis caused by either overproduction or underutilization of lactic acid. Overproduction of lactic acid, known as type A lactic acidosis, is frequent in critically ill patients with hypoperfusion states. Underutilization
Coskun, Ramazan, Elay, Gulseren, Bahar, Ilhan, GÜNDOĞAN, KÜRŞAT, Mumcuoglu, Haluk   +4 more
core   +1 more source

COX14 Variants Are Associated With Mitochondrial Complex IV Deficiency Nuclear Type 10 (MC4DN10)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT COX14 encodes a transmembrane protein essential for cytochrome c oxidase (COX) complex assembly. A homozygous missense variant in COX14 was reported in three siblings from a single consanguineous family with severe, fatal infantile mitochondrial complex IV deficiency nuclear type 10 (MC4DN10; MIM# 619053).
Elias K. Awad, Emily Waskow, Hari Tunuguntla, Joseph Spinner, Hanna J. Tadros, Lisa T. Emrick, Daniel G. Calame, Fernando Scaglia   +7 more
wiley   +1 more source

Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting

, 2016
Introduction : Dilutional acidosis may result from the introduction of a large fluid volume into the patients’ systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial ...
Miriam Petersen, Serhat Sönmez, Konstantinos Tsagakis, Herbert de Groot, Daniel-Sebastian Dohle, Rabea Verhaegh, Heinz Jakob, Johanna Katharina Teloh   +7 more
core   +1 more source

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation.
Nishitha R. Pillai, Sara A. Elsbecker, Grace Bronken McCarthy, Kaitlin Weisshappel, Peter Karachunski, Fernando Scaglia   +5 more
wiley   +1 more source

Factors associated with lactic acidosis in HIV patients on antiretroviral therapy in Harare city- 2012

, 2019
Introduction: Antiretroviral medicines have side effects that can be life threatening. An unpublished study by Malunga in Harare City, showed a high incidence of hyperlactatemia in patients on stalanev.
Choto, Emmaculate
core   +1 more source

Baseline characteristics of patients with metformin-associated lactic acidosis.

, 2022
Baseline characteristics of patients with metformin-associated lactic acidosis.
Laddaporn Wongluechai (13531716), Boonchan Phonyangnok (13531713), Watthikorn Pichitporn (13531719), Kanin Thammavaranucupt (10151220), Arkom Nongnuch (7334876), Kulapong Jayanama (10151217), Jirut Sumrittivanicha (13531722), Somnuek Sungkanuparph (427731), Watanyu Parapiboon (9703403)   +8 more
core   +1 more source

Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis

Military Medical Research, 2018
Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful.
Ying Wang, Ya Huang, Jing Yang, Fang-Qiang Zhou, Lian Zhao, Hong Zhou   +5 more
doaj   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Comment on Point: Counterpoint "Lactic acid is/is not the only physicochemical contributor to the acidosis of exercise"

, 2008
to the editor: I benefited from reading this Point:Counterpoint discussion (2, 3) and some of the papers cited therein and was shocked to learn that the construct of “lactic acidosis” has been questioned before..
Robergs, R.A.
core   +1 more source