Results 31 to 40 of about 215,605 (258)
Severe Metabolic Acidemia in a Patient with Aleukemic Leukemia
Case Reports in Nephrology, 2018 Malignancy associated lactic acidosis is a rare metabolic complication that may accompany various types of malignancies. To date, most cases that have been reported are associated with hematologic malignancies (lymphoma and leukemia).
Moutaz Ghrewati +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou +6 more
wiley +1 more source
Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study.
PLoS ONE, 2018 BackgroundMetformin constitutes first-line treatment of type 2 diabetes mellitus. It is presumed to have lactic acidosis as a dangerous, but rare, side effect.ObjectivesTo estimate the incidence rate of lactic acidosis in patients with type 2 diabetes ...
Abdellatif Aharaz +5 more
doaj +1 more source
Lactic Acidosis in Diabetes [PDF]
BMJ, 1969 Lactic acidosis is occasionally responsible for metabolic acidosis in diabetics. It may occur in the presence of normal blood levels of the ketone bodies, and such cases are often described as having “non-ketotic diabetic acidosis.” Lactic acid may contribute to the metabolic acidosis in patients with true diabetic ketoacidosis, but the blood lactate ...
P J, Watkins +3 more
openaire +2 more sources
pH‐Responsive Synthetic Cells for Programmable In Situ Protein Synthesis and Release
Advanced Materials, EarlyView.A synthetic cell is engineered to convert environmental acidification into nucleic acid signaling that activates protein synthesis. By coupling proton‐channel sensing, pH‐responsive DNA transduction, and toehold‐regulated translation, the platform enables acid‐triggered protein production within hydrogel‐embedded synthetic cells.
Sung‐Won Hwang +3 more
wiley +1 more source
Acidosis láctica asociada a metformina
, 2021 Lactic acidosis is an adverse reaction related to metformin and is the main etiology of metabolic acidosis. An annual incidence of lacticacidosis of 4.3 cases per 100 000 users of this drug has been reported, which is a considerable amount considering ...
Vallejos Narváez, Alvaro +5 more
core +1 more source
Thiamine Therapy During Refractory Lactic Acidosis in Critically Ill Children [PDF]
Introduction: Thiamin deficiency, which is an overlooked but important cause of lactic acidosis, can lead to several clinical symptoms, including neuropathy, cardiogenic shock, and death, even though it can be easily treated in critically ill children ...
Burak Balaban +8 more
core +1 more source
A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle
Advanced Science, EarlyView.This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin +9 more
wiley +1 more source
The Scientific World Journal, 2011 Most of the information about type B lactic acidosis associated with cancer is derived from case reports and there are no randomized controlled trials to compare different therapeutic modalities.
Juan P. Ruiz, Ashok Singh, Peter Hart
doaj +1 more source
Case Reports in Oncology, 2020 Lactic acidosis is pathophysiologically classified into type A and type B. The latter is a rare but potentially life-threatening emergency, mainly described in hematological malignancies.
Takafumi Hamada +5 more
doaj +1 more source