Results 11 to 20 of about 41,340 (258)

Alkali Therapy in Lactic Acidosis

Marshall Journal of Medicine, 2015
This report attempts to frame the debate about clinical administration of sodium bicarbonate in the setting of lactic acidosis in terms of simple questions.
Malhotra,, Deepak, MD, Tzamaloukas,, Antonios H, MD, Khitan,, Zeid J, MD, Raj,, Dominic S, MD, Shapiro,, Joseph I, MD   +4 more
core   +3 more sources

Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis

Military Medical Research, 2018
Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful.
Ying Wang, Ya Huang, Jing Yang, Lian Zhao, Fang-Qiang Zhou, Hong Zhou   +5 more
core   +2 more sources

Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report

Saudi Pharmaceutical Journal, 2022
Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang, Fan Zhang, Zhong Chen, Rui Huang, Juan Xia, Jinchun Liu   +5 more
doaj   +1 more source

Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. [PDF]

PLoS Genetics, 2010
Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer
Julia Ling-Yu Chen, Daniel Merl, Christopher W Peterson, Jianli Wu, Patrick Yantyng Liu, Hanwei Yin, Deborah M Muoio, Don E Ayer, Mike West, Jen-Tsan Chi   +9 more
doaj   +1 more source

Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics

Scientific Reports, 2020
Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis. Acidosis and lactic acidosis can induce different responses in tumors. Previous
Jiayue Gao, Zhiying Guo, Jianhua Cheng, Bo Sun, Jie Yang, Haijing Li, Shengming Wu, Fangting Dong, Xianzhong Yan   +8 more
doaj   +1 more source

Hypoglycemia with lactic acidosis caused by a new MRPS2 gene mutation in a Chinese girl: a case report

BMC Endocrine Disorders, 2022
Background Mitochondrial ribosomal protein S2 (MRPS2) gene mutation, which is related to severe hypoglycemia and lactic acidosis, is rarely reported globally. Case presentation We report a case of a new MRPS2 gene mutation in a Chinese girl who presented
ChangZhi Liu, WeiRan Zhou, QuanE Liu, ZaiXin Peng   +3 more
doaj   +1 more source

Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma

Case Reports in Critical Care, 2023
Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic ...
Ikemsinachi C. Nzenwa, Margaret Berquist, Toby J. Brenner, Aida Ansari, Hamid D. Al-Fadhl, Michael Aboukhaled, Shivani S. Patel, Ethan E. Peck, Mahmoud D. Al-Fadhl, Anthony V. Thomas, Nuha Zackariya, Mark M. Walsh, Jose A. Bufill   +12 more
doaj   +1 more source

Cochlear Implantation in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome: Case Presentation

, 2022
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome is a multisystem, progressive neurodegenerative condition, and the most common mitochondrial cytopathy.
Manohar Bance, Gemma Crundwell, Crundwell, Gemma, Bance, Manohar, Peter Kullar, Kullar, Peter   +5 more
core   +1 more source

A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report

Journal of Medical Case Reports, 2019
Background Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin.
Hiroki Kinoshita, Machi Yanai, Koichi Ariyoshi, Motozumi Ando, Ryo Tamura   +4 more
doaj   +1 more source

Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature

Case Reports in Medicine, 2009
Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of
Farn Huei Chan, Daniel Carl, Laurel J. Lyckholm   +2 more
doaj   +1 more source