Results 141 to 150 of about 95,231 (345)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

open access: yesAngewandte Chemie International Edition, EarlyView.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl   +6 more
wiley   +1 more source

Smallanthus sonchifolius (Yacon) leaves: an emerging source of compounds for diabetes management [PDF]

open access: yes, 2015
Diabetes mellitus is a chronic metabolic disease that develops mainly due to insulin deficiency or resistance to insulin action. All forms of diabetes are characterized by chronic hyperglycemia, which has an important role in the pathogenesis of diabetic
Genta, Susana Beatriz de Fátima   +2 more
core  

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

open access: yesAngewandte Chemie International Edition, EarlyView.
Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp   +8 more
wiley   +1 more source

The Rearrangement of cis-2-en-4:6-diyn-oic Acids to alphabeta-Unsaturated gamma-Lactones. [PDF]

open access: bronze, 1957
Per Koch Christensen   +4 more
openalex   +1 more source

Tautomeric Equilibria Studies by Mass Spectrometry [PDF]

open access: yes, 2008
Tautomerism in organic chemistry has been extensively studied in condensed phase by spectrometric methods, mainly by IR and NMR techniques. Mass spectrometry studies start 40 years ago but just recently it has been recognized the importance of the mass ...
Eduardo A. Castro   +3 more
core   +1 more source

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