Results 111 to 120 of about 102,744 (263)

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

open access: yesBrain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari   +10 more
wiley   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Prevalence and Sociodemographic Variation of Allergic Diseases in Australia: Findings From the Australian National Health Survey

open access: yesClinical &Experimental Allergy, EarlyView.
Using data from 17,093 participants in the 2022 Australian National Health Survey, this study is the first to report nationwide prevalence estimates for allergic rhinitis (23.9%), food allergy (7.0%), drug allergy (5.2%), eczema (1.6%) and diagnosed asthma (10.8%) across Australia.
Yichao Wang   +14 more
wiley   +1 more source

Pharmacological and non‐pharmacological interventions for managing sleep disorders in children with cerebral palsy: A systematic review

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
xxxxxx Aim To systematically review the effectiveness, safety, and economic evidence of pharmacological and non‐pharmacological interventions for sleep disorders in children with cerebral palsy (CP). Method Databases including MEDLINE, Embase, CENTRAL (the Cochrane Library), International Clinical Trials Registry Platform of the World Health ...
Nishant Jaiswal   +11 more
wiley   +1 more source

Insights into tandem dioxygenases—copper radical oxidases in fungal Phytopathogens of the Colletotrichum acutatum species complex

open access: yesThe FEBS Journal, EarlyView.
In Colletotrichum acutatum species complex, conserved ring‐cleavage dioxygenases located adjacent to AA5_2 enzymes were investigated as potential redox partners. Biochemical analyses identified the dioxygenases as intradiol‐cleaving enzymes preferentially oxidizing methyl‐substituted catechols, while AA5_2 enzymes displayed weak alcohol oxidase ...
Radka Končitíková   +7 more
wiley   +1 more source

Genetic and Phenotypic Correlations Among Growth, Disease Occurrence, and Reproductive Performance From Calf to Heifer in Girolando Dairy Cattle

open access: yesJournal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Girolando breed, a cross between Holstein (Bos taurus) and Gir (Bos indicus), is the primary choice for dairy production in Brazilian tropical regions, as it combines high productive potential with adaptation to the tropical environment.
Laura B. da C. Pereira   +6 more
wiley   +1 more source

Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta‐Analysis

open access: yesJournal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To identify risk factors/indicators of gingival enlargement (GE) and to summarise evidence for its management. Methods A systematic review was undertaken following PRISMA guidelines and divided into PECOTS and PICOTS questions, related to risk factors/indicators and treatment studies, respectively.
Luigi Nibali   +5 more
wiley   +1 more source

Isolation and Identification of Erysipelothrix sp. in Hybrid Grouper (Epinephelus fuscoguttatus × E. lanceolatus) in Taiwan

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT In February 2025, a mortality event of unknown aetiology occurred at a hybrid grouper (Epinephelus fuscoguttatus × Epinephelus lanceolatus) aquaculture farm in southern Taiwan, with sporadic daily deaths persisting for a month. Four moribund groupers were collected over three sampling intervals for diagnostic investigation.
Shang‐Ting Wu   +2 more
wiley   +1 more source

Vinegar–hydrogen peroxide for cleaning removable partial dentures: Antibiofilm efficacy and electrochemical degradation on a cobalt–chromium surface

open access: yesJournal of Prosthodontics, EarlyView.
Abstract Purpose This study evaluated the antibiofilm activity and electrochemical degradation effects of a combined solution of alcohol vinegar with 4% acetic acid and 3% hydrogen peroxide (3:1 by volume) on a cobalt–chromium (Co–Cr) surface.
Fernanda Zanelatto de Castro Paiva   +7 more
wiley   +1 more source

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