Results 71 to 80 of about 7,301 (235)

Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids

Journal of Lipid Research, 2010
The dihydroceramide, ceramide, sphingomyelin, lactosylceramide, and ganglioside species of A2780 human ovarian carcinoma cells treated with the synthetic retinoids N-(4-hydroxyphenyl)retinamide (fenretinide, 4-HPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide
Manuela Valsecchi, Massimo Aureli, Laura Mauri, Giuditta Illuzzi, Vanna Chigorno, Alessandro Prinetti, Sandro Sonnino   +6 more
doaj   +1 more source

Lactosylceramide in inflammatory bowel disease: a biochemical study. [PDF]

Gut, 1988
A simple technique for isolating lipids from small pieces of tissue was applied to mucosal biopsies and samples of resected intestine from patients with inflammatory bowel disease. Scanning densitometry of two dimensional chromatograms showed increased concentrations of the membrane associated glycosphingolipid lactosylceramide in Crohn's disease, on ...
C R, Stevens, V G, Oberholzer, J A, Walker-Smith, A D, Phillips   +3 more
openaire   +2 more sources

Metabolome Atlas of Brain Reveals Regional Shared and Unique Metabolic Drifts in Response to Type 2 Diabetes in Male Mice

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
A detailed metabolome atlas of the male mouse brain was established, incorporating metabolomic and lipidomic profiling of seven anatomical regions. T2D induced marked metabolic alterations, which were mainly associated with lipotoxicity, defective energy metabolism, proinflammatory processes, and neurotoxicity.
Yang Zhou, Yitong Lu, Zhaobao Wang, Xiaoqian Du, Bei Jiang, Qiuhui Xuan   +5 more
wiley   +1 more source

Alternation in the glycolipid transfer protein expression causes changes in the cellular lipidome. [PDF]

PLoS ONE, 2014
The glycolipid transfer protein (GLTP) catalyzes the binding and transport of glycolipids, but not phospholipids or neutral lipids. With its all-alpha helical fold, it is the founding member for a new superfamily, however its biological role still ...
Matti A Kjellberg, Anders P E Backman, Henna Ohvo-Rekilä, Peter Mattjus   +3 more
doaj   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI

npj Parkinson's Disease, 2021
Protein-coding variants in the GBA gene modulate susceptibility and progression in ~10% of patients with Parkinson’s disease (PD). GBA encodes the β-glucocerebrosidase enzyme that hydrolyzes glucosylceramide.
Young Eun Huh, Hyejung Park, Ming Sum Ruby Chiang, Idil Tuncali, Ganqiang Liu, Joseph J. Locascio, Julia Shirvan, Samantha J. Hutten, Melissa S. Rotunno, Catherine Viel, Lamya S. Shihabuddin, Bing Wang, Sergio Pablo Sardi, Clemens R. Scherzer   +13 more
doaj   +1 more source

Cytosolic Glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease [PDF]

, 2019
A new paradigm for Niemann-Pick C disease is presented where lysosomal storage leads to a deficit in cytoplasmic glucosylceramide (GlcCer) where it performs important functions.
Bhardwaj, Meenakshi, Haberkant, Per, Schmid, Ralf, Sillence, Daniel J., Tongue, Paige, Wheeler, S.   +5 more
core   +1 more source

Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

BioEssays, Volume 48, Issue 1, January 2026.
Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige, Yves Mély, Toshihide Kobayashi   +2 more
wiley   +1 more source

Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production

PLoS ONE, 2015
Degradation of elastin leads to the production of elastin-derived peptides (EDP), which exhibit several biological effects, such as cell proliferation or protease secretion.
A. Scandolera, F. Rabenoelina, Carine Chaintreuil, A. Rusciani, P. Maurice, S. Blaise, B. Romier-Crouzet, H. El Btaouri, L. Martiny, L. Debelle, L. Duca   +10 more
semanticscholar   +1 more source

An improved technique for separation of neutral glycosphingolipids by high-performance liquid chromatography

Journal of Lipid Research, 1980
We have developed a high-performance liquid chromatographic (HPLC) procedure for separation of O-acetyl-N-p-nitrobenzoyl derivatives of six neutral glycosphingolipids: glucosylceramide, lactosylceramide, globotriaosylceramide, lactotriaosylceramide ...
A Suzuki, S K Kundu, D M Marcus
doaj   +1 more source