Results 81 to 90 of about 7,301 (235)

24R,25(OH)2D3 regulates tumorigenesis in estrogen sensitive laryngeal cancer cells via membrane‐associated receptor complexes in ER+ and ER− cells

International Journal of Cancer, Volume 158, Issue 1, Page 202-217, 1 January 2026.
What's new? Estrogen receptors likely influence the development of laryngeal cancer and are of particular interest in regard to their relationship with the vitamin D metabolite 24R,25(OH)2D3. In this study the authors examined interactions between 24R,25(OH)2D3 and estrogen‐responsive laryngeal tumorigenesis.
Cydney D. Dennis, D. Joshua Cohen, Kusal Debnath, Nofrat Schwartz, Brock P. Lodato, Jonathan T. Dillon, Tillat Batool, Matthew S. Halquist, Preetam Ghosh, Zvi Schwartz, Barbara D. Boyan   +10 more
wiley   +1 more source

Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities [PDF]

, 2019
Trichothecene mycotoxins are recognized as highly bioactive compounds that can be used in the design of new useful bioactive molecules. In Trichoderma brevicompactum, the first specific step in trichothecene biosynthesis is carried out by a terpene ...
Bastien Cautain, Beremand, Dewick, Enrique Monte, Firn, Francisca Vicente, Isidro G. Collado, Javier E. Barúa, Mercedes de la Cruz, Nuria de Pedro, Plattner, Proctor, Rosa E. Cardoza, Rosa Hermosa, Santiago Gutiérrez   +14 more
core   +2 more sources

Lactosylceramide stimulates aortic smooth muscle cell proliferation

Biochemical and Biophysical Research Communications, 1991
We have investigated the effects of various sphingolipids on aortic smooth muscle cell proliferation employing viable cell counting, [3H] thymidine incorporation into DNA and the release of lactate dehydrogenase. Assays for UDP Gal: GlcCer Bl-4 galactosyltransferase (GalT-2) in control and treated cells were pursued simultaneously.
openaire   +2 more sources

From Molecule to Meaning: Neuronopathic Biomarkers and Clinical Relevance in GM1

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT GM1 gangliosidosis is a rare, progressively neurodegenerative lysosomal storage disorder characterized by profound central nervous system involvement and substantial clinical heterogeneity. The development of reliable biomarkers is essential for tracking disease progression, stratifying patients, and advancing clinical trial readiness. Primary
Krista Casazza, Roberto Giugliani, Debra S. Regier, Jeanine Jarnes   +3 more
wiley   +1 more source

Lactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes

Glycobiology, 2014
Hypertrophy is central to several heart diseases; however, not much is known about the role of glycosphingolipids (GSLs) in this phenotype. Since GSLs have been accorded several physiological functions, we sought to determine whether these compounds ...
Sumita Mishra, S. Chatterjee
semanticscholar   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

The structure of the tetrasialoganglioside from human brain [PDF]

, 1980
Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle- age onset. In nine families, we identified heterozygous C- terminal frameshift mutations in TREX1, which encodes a 3'-5' exonuclease ...
AC Cohn, Andreas Gschwendter, Anine H Stam, Anna Richards, Arn M J M van den Maagdenberg, Boukje de Vries, Caroline W Storimans, CW Storimans, D Chowdhury, D Martinvalet, David Kavanagh, Dirk Spitzer, DJ Mazur, DJ Mazur, F Goutieres, G Rice, Gisela M Terwindt, GM Terwindt, Hafsa Mamsa, J Jen, Jendo A Oosterhuis, Jijun Wan, Joanna C Jen, John P Atkinson, Joost Haan, Kaate R J Vanmolkot, Katya E Kotschet, M Hoss, M Kathryn Liszewski, Maria-Louise Barilla-LaBarca, Mark Gilbert Grand, Martin B Delatycki, Martin Dichgans, Mary J van Schooneveld, MG Grand, Michael J Kane, Michel D Ferrari, Mike McLellan, Parul H Kothari, Paula Bertram, Paulus T V M de Jong, RA Ophoff, Robert W Baloh, Rula A Hajj-Ali, Rune R Frants, Ruth Schäfer, S Weil, Stanley F Nelson, Suzanne Hodgkinson, Todd A Hardy, YJ Crow, Yumi Kasai   +51 more
core   +2 more sources

A hemolytic anti‐LKE associated with a rare LKE‐negative, “weak P” red blood cell phenotype: alloanti‐LKE and alloanti‐P recognize galactosylgloboside and monosialogalactosylgloboside (LKE) antigens [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110583/1/trf12772 ...
Cooling, Laura, Dake, Louann R., Ellis, Susie, Haverty, Donna, Judd, W. John, Mullis, Nancy, Shayman, James   +6 more
core   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Goodfellow, Goodyear, Greenshields, Halstead, Handa, Jacobs, Kaida, Kaida, Kaida, Kaida, Kaida, Kuijf, Kusunoki, McGonigal, Notturno, O’Hanlon, O’Hanlon, Plomp, Plomp, Svennerholm, van Doorn, Willison, Zitman   +22 more
core   +1 more source