Results 71 to 80 of about 4,156 (155)

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, Volume 41, Issue 3, Page 581-595, March 2026.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

Cell surface expression of ceramide and complex sphingolipids.

, 2016
Depicted is the mean fluorescence intensity as analyzed by flow cytometry using monoclonal antibodies for ceramide, lactosylceramide globotriaosylceramide and dodecasaccharideceramide, and cholera toxin subunit B for ganglioside GM1 after MCSF ...
Evelyn Orsó (3356972), Markus Peer (282482), Andrzej Sobota (541758), Margot Grandl (44448), Gerd Schmitz (44452), Stefan Wallner (548742), Gerhard Liebisch (78400), Alexander Sigrüner (548744)   +7 more
core   +1 more source

Current Topics in Pharmacological Research on Bone Metabolism: Osteoclast Differentiation Regulated by Glycosphingolipids

Journal of Pharmacological Sciences, 2006
.: Glycosphingolipids are thought to play important roles in the development and function of several tissues, although the function of glycolipids in osteoclastogenesis has not been clearly demonstrated.
Satoshi Fukumoto, Tsutomu Iwamoto, Eiko Sakai, Kenji Yuasa, Emiko Fukumoto, Aya Yamada, Tomokazu Hasegawa, Kazuaki Nonaka, Yuzo Kato   +8 more
doaj   +1 more source

Role of very long fatty acid-containing glycosphingolipids in membrane organization and cell signaling : the model of lactosylceramide in neutrophils

, 2009
Glycosphingolipids are highly enriched in specialized membrane microdomains ("lipid rafts", caveolar domains and glycosynapses), and they participate to the process of transduction of information across the membrane.
Sandro Sonnino, Alessandro Prinetti, Mitsuaki Yangida, M. Yangida, K. Iwabuchi, A.E.G. Prinetti, Kazuhisa Iwabuchi, Hitoshi Nakayama, S. Sonnino, Hideoki Ogawa, H. Ogawa, H. Nakayama   +11 more
core   +1 more source

Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus

, 2002
Multidrug-resistant tumor cells display enhanced levels of glucosylceramide. In this study, we investigated how this relates to the overall sphingolipid composition of multidrug-resistant ovarian carcinoma cells and which mechanisms are responsible for ...
John Hinrichs, Sietsma, H, Hinrichs, J, Ina Hummel, Hannie Sietsma, van der Schaaf, G, Klappe, K, Veldman, RJ, Hummel, I, Gieta Schaaf, Jan Willem Kok, Kok, J W, Karin Klappe, Hummel, [No Value], Veldman, R J, Robert Jan Veldman, Kok, JW   +16 more
core   +1 more source

Α-Lactosylceramide as a Novel “Sugar-Capped” CD1d Ligand for Natural Killer T Cells: Biased Cytokine Profile and Therapeutic Activities

, 2008
The invariant natural killer T cells (iNKT) cells have emerged as an important regulator of immunity to infection, cancer, and autoimmune diseases. They can be activated by glycolipids that bind to CD1d. The most effective iNKT ligand reported to date is
Perali, Ramu Sridhar, Zheng, Xincheng, Chengfeng Xia, Liu, Yang, Yang Liu, Peng George Wang, Pan Zheng, Xincheng Zheng, Zheng, Pan, Wang, Peng George, Zhang, Wenpeng, Yao, Qingjia, Ramu Sridhar Perali, Wenpeng Zhang, Qingjia Yao, Xia, Chengfeng   +15 more
core   +1 more source

Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic Escherichia coli.

PLoS ONE, 2011
Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing
Annelies Coddens, Erik Valis, John Benktander, Jonas Ångström, Michael E Breimer, Eric Cox, Susann Teneberg   +6 more
doaj   +1 more source

Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production. [PDF]

, 2015
Degradation of elastin leads to the production of elastin-derived peptides (EDP), which exhibit several biological effects, such as cell proliferation or protease secretion.
Béatrice Romier-Crouzet, Duca, Laurent, Sébastien Blaise, Rabenoelina, Fanja, Laurent Martiny, El Btaouri, Hassan, Fanja Rabenoelina, Laurent Debelle, Martiny, Laurent, Chaintreuil, Carine, Blaise, Sébastien, Amandine Scandolera, Pascal Maurice, Scandolera, Amandine, Anthony Rusciani, Debelle, Laurent, Hassan El Btaouri, Romier-Crouzet, Beatrice, Laurent Duca, Rusciani, Anthony, Carine Chaintreuil, Maurice, Pascal   +21 more
core   +2 more sources

Lactosylceramide: Lateral Interactions with Cholesterol [PDF]

, 2006
Lactosylceramide (LacCer) is a key intermediate in glycosphingolipid metabolism and is highly enriched in detergent-resistant biomembrane fractions associated with microdomains, i.e., rafts and caveolae. Here, the lateral interactions of cholesterol with
Li, Xin-Min, Zhai, Xiuhong, Momsen, Maureen M., Brockman, Howard L., Brown, Rhoderick E.   +4 more
core   +1 more source