Lambert-Eaton Myasthenic Syndrome [PDF]
Neurologic Clinics, 2018 Lambert-Eaton myasthenic syndrome is a paraneoplastic or primary autoimmune neuromuscular junction disorder characterized by proximal weakness, autonomic dysfunction and ariflexia. The characteristic symptoms are thought to be caused by antibodies generated against the P/Q-type voltage-gated calcium channels present on presynaptic nerve terminals and ...
Vita G, Kesner +3 more
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Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update [PDF]
Brain Sciences, 2021 The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration ...
Maria Pia Giannoccaro +2 more
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Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study [PDF]
BMC NeurologyThis is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm.
David P. Randall, Matthew C. Randall
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Efficacy of durvalumab plus chemotherapy in small-cell lung cancer with Lambert-Eaton myasthenic syndrome [PDF]
Respiratory Medicine Case ReportsLambert-Eaton myasthenic syndrome (LEMS) is a rare disease but is often associated with small-cell lung cancer (SCLC). We discuss the case of a 65-year-old man diagnosed with SCLC-LEMS and treated with carboplatin, etoposide, and durvalumab.
Naoya Ishibashi +7 more
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The Case of a 28‐Year‐Old Man With Gradually Progressive Proximal Leg Weakness
Annals of Clinical and Translational NeurologyThis is a case of a 28‐year‐old man who presented with a 6‐month history of gradually progressive proximal leg weakness and pain that worsened on exercise and was relieved by rest. He had no symptoms in his upper limbs.
Melody T. Asukile +3 more
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A rare case of concomitant Lambert-Eaton myasthenic syndrome and syndrome of inappropriate antidiuretic hormone secretion in a patient with small cell lung carcinoma. [PDF]
Respir Med Case Rep, 2023 Small cell lung carcinoma (SCLC) is a neuroendocrine carcinoma with a poor prognosis and is a common cause of paraneoplastic syndromes. Paraneoplastic syndromes are characterized by neurological and endocrinological problems in patients with malignancy ...
Oda Y +9 more
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Relapse of both small cell lung cancer and Lambert–Eaton myasthenic syndrome after a 13-year disease-free survival period [PDF]
Chinese Journal of Cancer, 2016 Lambert–Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare.
Fumio Asano +10 more
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Burden of disease in Lambert-Eaton myasthenic syndrome: taking the patient's perspective. [PDF]
J NeurolBackground: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune-mediated neuromuscular disorder leading to muscle weakness, autonomic dysregulation and hyporeflexia. Psychosocial well-being is affected. Previously, we assessed burden of disease for
Lehnerer S +8 more
europepmc +3 more sources
The European Lambert-Eaton Myasthenic Syndrome Registry: Long-Term Outcomes Following Symptomatic Treatment. [PDF]
Neurol Ther, 2022 Meisel A +4 more
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Lambert-Eaton myasthenic syndromes [PDF]
Journal of the Neurological Sciences, 2019 K. El Salem
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