Results 41 to 50 of about 4,373 (200)
PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 859-871, April 2026.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou +14 more
wiley +1 more source
Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update
Brain Sciences, 2021 The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration ...
Maria Pia Giannoccaro +2 more
doaj +1 more source
The Relationship Between Immune Semaphorins and Myasthenia Gravis
Brain and Behavior, Volume 16, Issue 3, March 2026.Serum alterations of immune‐related semaphorins in myasthenia gravis. Patients exhibited decreased semaphorin 4A and increased semaphorin 7A levels compared with healthy controls. These changes highlight disturbed immune regulation in myasthenia gravis and support the involvement of semaphorin‐mediated pathways in autoimmune neuromuscular junction ...
Dilcan Kotan +2 more
wiley +1 more source
Lambert-Eaton myasthenic syndrome revealing an abdominal neuroblastoma.
, 2009 Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome that may reveal a primitive tumor. Neuroblastoma in children and small cell lung carcinoma in adults are the leading tumors revealed or expressed by paraneoplastic phenomena.
de Buys Roessingh, A.S. +3 more
core +1 more source
Paraneoplastic Motor Neuropathy in Nodular Sclerosis Hodgkin’s Lymphoma: Case Report
Case Reports in Hematology, Volume 2026, Issue 1, 2026.Paraneoplastic neurological syndromes (PNS) are an uncommon complication of malignancy, characterized by autoantibody generation against neuronal structures, causing a spectrum of neurological syndromes affecting the central, peripheral, and/or autonomic nervous systems. PNS in lymphoma is exceedingly rare and there is limited evidence on the features,
Jayesh Menon +4 more
wiley +1 more source
Poorly differentiated carcinoma of the lung presenting with Lambert-Eaton myasthenic syndrome
, 2000 Lambert-Eaton myasthenic syndrome commonly seen in small-cell lung cancer represents an autoimmune reaction against antigens coexpressed by tumor and neurons. It is rarely seen with other histologic subtypes.
Kumar, BS, Nair, SG, Rajan, B
core +1 more source
Lambert-Eaton Myasthenic Syndrome; Pathogenesis, Diagnosis, and Therapy [PDF]
, 2011 Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare disease with a well-characterized pathogenesis. In 50% of the patients, LEMS is a paraneoplastic manifestation and caused by a small cell lung carcinoma (SCLC).
Nils Erik Gilhus
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A Case of Voltage‐Gated Calcium Channel and TG6 Antibody–Positive Cerebellar Ataxia
Case Reports in Neurological Medicine, Volume 2026, Issue 1, 2026.We present the case of a lady in her early 20s who developed over a few weeks progressive appendicular and limb ataxia and dysarthria. She was found to have a high titer of voltage‐gated calcium channel antibodies (VGCCAs) and was started on immunosuppressive and immunomodulating therapy with no further worsening of her neurological status.
Alberto Cifelli +4 more
wiley +1 more source
Concurrent Paraneoplastic Neuromyelitis Optica and Lambert-Eaton Myasthenic Syndrome
, 2023 Lambert-Eaton Myasthenic Syndrome (LEMS) is uncommon and associated with small cell lung cancer (SCLC). Neuromyelitis optica spectrum disorder (NMOSD) is rare, and has also been reported in association with malignancy, most commonly, breast ...
Haley D\u27Souza; M. Tariq Bhatti; Andrew McKeon; John Chen; Deena Tajfirouz
core
Case Reports in Oncological Medicine, Volume 2026, Issue 1, 2026.Exophthalmos is most often associated with autoimmune thyroid disease, particularly Graves disease. Paraneoplastic syndromes rarely manifest as orbital inflammation, and only a few cases have been described in association with solid tumors. We present a case of a 67‐year‐old male diagnosed with esophageal cancer.
Yara E. Tovar +2 more
wiley +1 more source