Results 231 to 240 of about 92,845 (317)

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations? [PDF]

Med Sci (Basel)
Erokhina MA, Vorotelyak EA, Vasiliev AV, Abdyev VK.   +3 more
europepmc   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, Volume 40, Issue 3, Page 965-985, March 2026.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing. [PDF]

Nucleus
Renkawitz J, Yesin A, Kroll J, Cabral AT, D'Annunzio S, Thiam HR.   +5 more
europepmc   +1 more source

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target

Aging Cell, Volume 25, Issue 3, March 2026.
By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Mingzhu Zhang, Ziqi Hu, Shengwen Piao, Yingrui Song, Ying Jia, Jiaxing Liu, Ning Zhao, An Liu, Songbin Fu, Wenjing Sun, Hui Xu, Yu Yang, Steven P. Gygi, Chunshui Zhou   +13 more
wiley   +1 more source

Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration. [PDF]

Proc Natl Acad Sci U S A
Mahmud J, Nandi I, J Procter D, Walsh D.
europepmc   +1 more source

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels. [PDF]

Nat Commun
Cherdyntseva V, Paulson J, González-Acosta D, Ubieto-Capella P, Rodrigues M, Aouami M, Adakli S, Gagné JP, Bakker C, Poirier GG, Taneja N, Lopes M.   +11 more
europepmc   +1 more source

Lamin and the heart

Heart, 2017
G. Captur, E. Arbustini, G. Bonne, P. Syrris, K. Mills, K. Wahbi, Saidi A Mohiddin, W. McKenna, S. Pettit, Carolyn Y. Ho, A. Muchir, P. Gissen, P. Elliott, J. Moon   +13 more
semanticscholar   +1 more source

Ticks and tick‐borne bacterial pathogens found on hard ticks (Acari: Ixodidae) on cattle in the Central River region of The Gambia

Medical and Veterinary Entomology, Volume 40, Issue 1, Page 91-100, March 2026.
First detection of Ehrlichia minasensis, Anaplasma marginale and hemotropic Mycoplasma spp. in cattle in The Gambia. Identification of four tick species, with Hyalomma marginatum being the most common. 15.6% of ticks tested positive for tick‐borne pathogens, including Ehrlichia spp., A. marginale and hemotropic Mycoplasma spp.
Alpha Kargbo, Aamir M. Osman, Edrisa Jawo, Lamin K. M. Fatty, Flavia C. M. Collere, Marcos R. André, Ahmed A. Hassan‐Kadle, Thállitha S. W. J. Vieira, Rosangela Z. Machado, Rafael F. C. Vieira   +9 more
wiley   +1 more source

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis. [PDF]

Nat Cell Biol
Lewis R, Sinigiani V, Maziak N, Koos K, Bersaglieri C, Zemp I, Ashiono C, Ciaudo C, Horvath P, Vaquerizas JM, Santoro R, Sharma P, Kutay U.   +12 more
europepmc   +1 more source