Results 251 to 260 of about 52,713 (325)

Age mosaic of gut epithelial cells prevents aging. [PDF]

Nat Commun
Qin P, Wang Q, Wu Y, You Q, Li M, Guo Z.
europepmc   +1 more source

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Lamin variants cause cardiac arrhythmogenicity in Drosophila.

Dis Model Mech
van Wijk SW, Vree P, Huiskes FG, van der Palen RL, Liutkute A, Voigt N, Wallrath LL, Brundel BJJM.   +7 more
europepmc   +1 more source

Optimizing Proximity Proteomics on the EvoSep‐timsTOF LC–MS System

PROTEOMICS, Volume 25, Issue 15, Page 58-71, August 2025.
ABSTRACT Proximity‐dependent biotinylation (BioID) is a powerful means of exploring the cellular environments in which proteins reside. Expressing a protein of interest (bait) fused to a biotin ligase and adding biotin induces the covalent biotinylation of proximal partners (preys), which are recovered on streptavidin beads and identified by MS ...
Julia Kitaygorodsky, Brendon Seale, Vesal Kasmaeifar, Reuben Samson, Zhen‐Yuan Lin, Martina Tersigni, Saya Sedighi, Cassandra J. Wong, Anne‐Claude Gingras   +8 more
wiley   +1 more source

Phosphatidylcholine suppresses inflammatory responses in LPS-stimulated MG6 microglial cells by inhibiting NF-κB/JNK/p38 MAPK signaling. [PDF]

PLoS One
Mizuno S, Kurobe-Takashima Y, Kuriki D, Susaki K, Otsuka K, Tsuchihashi T, Abe K, Kobayashi S.   +7 more
europepmc   +1 more source

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

The FEBS Journal, Volume 292, Issue 15, Page 3986-4005, August 2025.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe, Umberto Candia, Dario Sasso del Verme, Elvira Toscano, Marianna Toriello, Gaetano Sodaro, Roberta Rapuano, Simona Romano, Michela Grosso, Giovanni Paolella, Angelo Lupo, Paola Costanzo, Elena Cesaro   +12 more
wiley   +1 more source

Lamin A/C regulates cerebellar granule cell maturation. [PDF]

Cell Biol Toxicol
Vilardo L, Cifola I, Nardella M, Pelucchi P, Ciotti MT, Bianchi A, Rinaldi A, Arisi I, Brandi R, d'Onofrio M, Galvanetto N, Gatti G, Catalano M, Lanzuolo C, Guglielmi L, D'Agnano I.   +15 more
europepmc   +1 more source

SFPQ subcellular mislocalisation entails altered cancer cell function

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Libang Yang, Adam Gilbertsen, Blake Jacobson, Robert Kratzke, Yingming Li, Bo Sun, Sabine Karam, Scott M. Dehm, Craig A. Henke   +8 more
wiley   +1 more source

A Novel LAMA2 Mutation (c.7412G>A) Was Found in a Chinese Patient With Congenital Muscular Dystrophy

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Congenital muscular dystrophy (CMD) is a genetic muscle disorder characterised by muscle weakness and degeneration, either present at birth or emerging in middle age, often leading to progressive disability. MDC1A is a subtype of CMD caused by mutations in the LAMA2 gene.
Meifang Zhao, Yuxing Liu, Liangliang Fan, Zhaochuan Liu, Yao Deng, Lihong Tao   +5 more
wiley   +1 more source

Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology. [PDF]

Proc Natl Acad Sci U S A
Saito A, Nagayama K, Okada H, Onodera S, Aida N, Nakamura T, Sawada T, Hojo H, Kato S, Azuma T.   +9 more
europepmc   +1 more source