Results 81 to 90 of about 53,083 (269)
Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity
Nature Communications, 2019 Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we use
A. Makarov +7 more
semanticscholar +1 more source
The Emerging Role of Lamin C as an Important LMNA Isoform in Mechanophenotype
Frontiers in Cell and Developmental Biology, 2018 Lamin A and lamin C isoforms of the gene LMNA are major structural and mechanotransductive components of the nuclear lamina. Previous reports have proposed lamin A as the isoform with the most dominant contributions to cellular mechanophenotype. Recently,
Rafael D. González-Cruz +3 more
doaj +1 more source
Measured lamination spaces for surface pairs [PDF]
arXiv, 2014 We calculate a projective space of essential measured laminations in a surface pair, which will be used in another paper to help describe spaces of "finite height laminations."
arxiv
Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus
BMC Molecular and Cell Biology, 2019 Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus as it also interacts with actin and ...
Devika Ranade +4 more
semanticscholar +1 more source
Triangulating stable laminations [PDF]
Electronic Journal of Probability, 2016 We study the asymptotic behavior of random simply generated noncrossing planar trees in the space of compact subsets of the unit disk, equipped with the Hausdorff distance. Their distributional limits are obtained by triangulating at random the faces of stable laminations, which are random compact subsets of the unit disk made of non-intersecting ...
Kortchemski, Igor, Marzouk, Cyril
openaire +6 more sources
Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
Nature Communications, 2019 The nuclear lamina—a meshwork of intermediate filaments termed lamins—is primarily responsible for the mechanical stability of the nucleus in multicellular organisms.
K. Sapra +6 more
semanticscholar +1 more source
Advanced Science, 2020 The cell nucleus is constantly subjected to externally applied forces. During metazoan evolution, the nucleus has been optimized to allow physical deformability while protecting the genome under load.
Oren Wintner +7 more
doaj +1 more source
Lamin A/C promotes DNA base excision repair.
Nucleic Acids Research, 2019 The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature aging disease Hutchinson-Gilford progeria ...
S. Maynard +9 more
semanticscholar +1 more source
Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology
Nature Communications, 2017 The distinct spatial architecture of the apical actin cables (or actin cap) facilitates rapid biophysical signaling between extracellular mechanical stimuli and intracellular responses, including nuclear shaping, cytoskeletal remodeling, and the ...
Jeong-Ki Kim +5 more
semanticscholar +1 more source
Measured flat geodesic laminations [PDF]
arXiv, 2014 Since their introduction by Thurston, measured geodesic laminations on hyperbolic surfaces occur in many contexts. In [Mor], we have introduced a notion of flat laminations on surfaces endowed with a half-translation structure (that is a singular flat surface with holonomy {+/-Id}, similar to geodesic laminations on hyperbolic surfaces.
arxiv