Results 81 to 90 of about 96,178 (343)

Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes

Nature Communications
Barrier-to-autointegration factor (BAF) associates with mitotic chromosomes and promotes nuclear envelope assembly by recruiting proteins, such as Lamins, required for the reconstruction of the nuclear envelope and lamina.
Naoki Horikoshi, Ryosuke Miyake, Chizuru Sogawa-Fujiwara, Mitsuo Ogasawara, Yoshimasa Takizawa, Hitoshi Kurumizaka   +5 more
doaj   +1 more source

MicroRNA-23a promotes myelination in the central nervous system. [PDF]

, 2013
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui, Heng, Mary Y, Huang, Yong, Lin, Shu-Ting, Ptácek, Louis J, Zhang, Luoying   +5 more
core   +2 more sources

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. [PDF]

, 1988
A cDNA clone encoding a portion of Drosophila nuclear lamins Dm1 and Dm2 has been identified by screening a lambda-gt11 cDNA expression library using Drosophila lamin-specific monoclonal antibodies.
Bare, JW, Benton, BM, Drees, B, Fisher, PA, Gruenbaum, Y, Landesman, Y, Paddy, MR, Saumweber, H, Sedat, JW, Smith, DE   +9 more
core   +1 more source

Structure and stability of the lamin A tail domain and HGPS mutant [PDF]

, 2011
Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging syndrome caused by the expression and accumulation of a mutant form of lamin A, Δ50 lamin A.
Buehler, Markus J, Dahl, Kris Noel, Kalinowski, Agnieszka, Qin, Zhao   +3 more
core   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Differential involvement of caspase-6 in amyloid-β-induced fragmentation of lamin A and B

Biochemistry and Biophysics Reports, 2020
Amyloid-β (Aβ), a peptide implicated in Alzheimer's disease, was shown to cause specific fragmentation of lamin proteins, which was mediated by an unidentified protease named nuclear scaffold protease (NSP) independently of caspase-6.
Md Imamul Islam, Md Selim Hossain, Il-Seon Park   +2 more
doaj   +1 more source

A Lamin Family-Based Signature Predicts Prognosis and Immunotherapy Response in Hepatocellular Carcinoma

Journal of Immunology Research, 2022
Background. Lamin family members play crucial roles in promoting oncogenesis and cancer development. The values of lamin family in predicting prognosis and immunotherapy response remain largely unclarified.
Yongyu Yang, Wang Xiao, Ruoqi Liu, Lei Gao, Junzhang Chen, Heping Kan   +5 more
doaj   +1 more source

Journal of African Christian Biography: v. 4, no. 2 [PDF]

, 2019
A publication of the Dictionary of African Christian Biography with U.S. offices located at the Center for Global Christianity and Mission at Boston University. This issue focuses on: 1.
Bonk, Jonathan J., Bratt, David, Oborji, Frances Anekwe, Restrick, Beth, Sanneh, Lamin, Sigg, Michèle Miller, Walls, Andrew, Watters, John R.   +7 more
core  

Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts

Genome Biology, 2017
Current three-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positions ...
Jonas Paulsen, M. Sekelja, Anja R. Oldenburg, Alice Barateau, N. Briand, E. Delbarre, Akshay Shah, Anita L. Sørensen, C. Vigouroux, B. Buendia, P. Collas   +10 more
semanticscholar   +1 more source