Results 181 to 190 of about 21,188,703 (341)

Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy [PDF]

, 2016
Gun West, Josef Gullmets, Laura Virtanen, Song-Ping Li, Anni Keinänen, Takeshi Shimi, Monika Mauermann, Tiina Heliö, Maija Kaartinen, Laura Ollila, Johanna Kuusisto, John Eriksson, Robert D. Goldman, Harald Herrmann, Pekka Taimen   +14 more
openalex   +1 more source

Evidence for Drop‐Like Nuclear Deformation in Sheared Endothelial Monolayers

Small, EarlyView.
Physiological shear stress smoothens endothelial monolayers by selectively eliminating less‐spread cells with tall, wrinkled nuclei. Nuclear volume and surface area remain constant, consistent with drop‐like deformation governed by geometric constraints.
Mohammad Mohajeri, Ting‐Ching Wang, Pooja Agarwal, Simran Kaur, Ankit Kumar, Richard B. Dickinson, Abhishek Jain, Tanmay P. Lele   +7 more
wiley   +1 more source

NMNAT1 Activates Autophagy to Delay D-Galactose-Induced Aging in Cochlear Hair Cells. [PDF]

Aging Cell
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Wei Y, Yang W, Wu H, Kong M, Fan D, Zhang Y, Cheng N, Du J, Guo L, Li Y, Zhang Y, Dai Q, Cao W, Yang J, Fang Q.   +14 more
europepmc   +2 more sources

Role of Lamin A and emerin in maintaining nuclear morphology in different subtypes of ovarian epithelial cancer

, 2021
Shiori Watabe, Sayaka Kobayashi, M Hatori, Yoshimi Nishijima, Naoki Inoue, Hayato Ikota, Akira Iwase, Hideaki Yokoo, Masanao Saio   +8 more
openalex   +2 more sources

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

The destruction of cytoplasmic skeleton leads to the change of nuclear structure and the looseness of lamin A submicroscopic network

Heliyon
The interaction between lamin A and the cytoplasmic skeleton plays a key role in maintaining nuclear mechanical properties. However, the effect of destruction of the cytoplasmic skeleton on the 3D submicroscopic structure of lamin A has not been ...
Zhenyu Yang, Xianglong Liu, Xiaoliang Li, Maurizio Abbate, Han Rui, Miao Guan, Zhenglong Sun   +6 more
doaj   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

SUN/KASH interactions facilitate force transmission across the nuclear envelope. [PDF]

, 2019
LINC complexes (Linker of Nucleoskeleton and Cytoskeleton), consisting of inner nuclear membrane SUN (Sad1, UNC-84) proteins and outer nuclear membrane KASH (Klarsicht, ANC-1, and Syne Homology) proteins, are essential for nuclear positioning, cell ...
Hao, Hongyan, Starr, Daniel A
core  

Elucidating the Functional Role of MLIP, a Novel Muscle A-type Lamin Interacting Protein

, 2011
Seham Rabaa
openalex   +1 more source

Assembly of lamins in vitro [PDF]

, 1996
Gung Wei Min, Tong Xiang, Bin Chen, Bo Zhang, Zhongfan Liu, Ming Ding, Zhong He Zhai   +6 more
openalex   +1 more source