GENDER FEATURES OF LAMINA CONTENT IN HUMAN SKIN FIBROBLASTS IN A PROCESS OF CHRONOLOGICAL AGING
Сибирский научный медицинский журнал, 2019 The purpose of the study was to investigate gender peculiarities of the content of fibroblasts immunopositive to lamins A, B1 and B2 in skin samples in a process of chronological aging. Material and methods.
N. N. Golubtsova +2 more
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Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases
Frontiers in Pharmacology, 2022 Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng +4 more
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Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone
Cells, 2020 Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into nucleus.
Natividad Alcorta-Sevillano +3 more
semanticscholar +1 more source
Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells. [PDF]
PLoS ONE, 2017 Nuclear lamins support the nuclear envelope and provide anchorage sites for chromatin. They are involved in DNA synthesis, transcription, and replication.
Ines Rauschert +7 more
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Nucleus, 2019 Lamin A, a product of the LMNA gene, is an essential nuclear envelope component in most differentiated cells. Mutations in LMNA have been linked to premature aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS).
Magda R. Hamczyk, Vicente Andrés
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Expression of Lamin A gene in periodontitis: A cross-sectional study [PDF]
Journal of Advanced Periodontology and Implant DentistryBackground. The host defense process against invading bacteria leads to the destruction of the periodontium. Lamin A is an important protein for protecting DNA and preventing premature cell aging.
Naser Sargolzaie +5 more
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Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells [PDF]
, 2011 Copyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund. This is an open access article distributed under the terms of the Creative Commons Attribution License ...
Arican, HD +4 more
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Annually laminated speleothems: a review
International Journal of Speleology, 2008 This review of annually laminated speleothems firstly considers the four types of annual laminae found within speleothems: fluorescentlaminae formed by annual variations in organic matter flux; visible or petrographic laminae, formed by annual variations in calcitetexture or fabric; calcite-aragonite couplets; and finally trace element laminae.
Baker, Andy +5 more
openaire +4 more sources
Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics [PDF]
Journal of Biological Chemistry, 2006 Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Cells lacking lamins A and C have reduced nuclear stiffness and increased nuclear fragility, leading to increased cell death under mechanical ...
Jan, Lammerding +6 more
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Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
Molecular Biology of the Cell, 2017 Micromanipulation force measurements of single isolated nuclei at physiological strains and strain rates reveal two distinct cell nuclear mechanical regimes differentially governed by chromatin and lamin A.
Andrew D. Stephens +4 more
semanticscholar +1 more source