Results 61 to 70 of about 118,592,744 (196)

Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan [PDF]

, 2018
Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria.
Teleri Clark, Thang M. Khuong, G. Gregory Neely, Yong Qi Lin, Lisa J. Oyston, Qiao-Ping Wang, Man Tat Lau   +6 more
core   +1 more source

An investigation of emerin and nuclear lamins: : Interactions, distribution, and role in cell cycle regulation, in cells derived from EDMD patients. [PDF]

, 2002
Emery Dreifuss muscular dystrophy (EDMD) is caused by mutations either in the gene encoding emerin or in the gene encoding A-type lamins (lamins A and C).
Maria, Choleza
core  

A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin

Advanced Science, 2020
The cell nucleus is constantly subjected to externally applied forces. During metazoan evolution, the nucleus has been optimized to allow physical deformability while protecting the genome under load.
Oren Wintner, Nivi Hirsch‐Attas, Miriam Schlossberg, Fani Brofman, Roy Friedman, Meital Kupervaser, Danny Kitsberg, Amnon Buxboim   +7 more
doaj   +1 more source

The multiple roles of A-type lamins in cellular aging, cell cycle progression and the DNA damage response. [PDF]

, 2011
A-type lamins are a group of type V intermediate filaments whose main members are lamin A and C. Lamins A/C are components of the nuclear lamina and are encoded by the LMNA gene.
GIBBS-SEYMOUR, IAN,DAVID
core  

The Emerging Role of Lamin C as an Important LMNA Isoform in Mechanophenotype

Frontiers in Cell and Developmental Biology, 2018
Lamin A and lamin C isoforms of the gene LMNA are major structural and mechanotransductive components of the nuclear lamina. Previous reports have proposed lamin A as the isoform with the most dominant contributions to cellular mechanophenotype. Recently,
Rafael D. González-Cruz, Kris N. Dahl, Eric M. Darling, Eric M. Darling   +3 more
doaj   +1 more source

Interactions between nuclear lamins and their binding partners in EDMD fibroblasts [PDF]

, 2003
Lamins are components of the nuclear lamina and are divided In A and B-types, which Interact with proteins of the inner nuclear membrane like emerin.
Alvarez-Reyes, Mauricio
core  

Lamin A/C and PI(4,5)P2—A Novel Complex in the Cell Nucleus

Cells
Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations.
Sara Escudeiro-Lopes, Vlada V. Filimonenko, Lenka Jarolimová, Pavel Hozák   +3 more
doaj   +1 more source

Anti-lamin A/C antibodies in patients with Behçet’s disease

Central European Journal of Immunology, 2018
Lamin A/C has been identified as a target antigen of anti-endothelial cell antibodies in vasculitis. Behçet’s disease (BD) is a chronic vasculitis with unclear pathogenesis.
Peng Chen, Hai Yan, Wen Zhang, Chunhe Yang, Hongwu Du   +4 more
doaj   +1 more source

Laminitis in horses [PDF]

In Practice, 2012
Laminitis is a common and painful condition of adult equids that often results in permanent lameness or euthanasia. In recent years, our knowledge of the condition has developed and this article discusses the current understanding of laminitis and approaches to its treatment and prevention.
openaire   +1 more source

Modulation of nuclear lamin-chromatin interactions by external cues

, 2020
The three-dimensional (3D) organization of chromatin in the mammalian cell nucleus plays an important role in the regulation of gene expression. In her Ph.D.
Forsberg, Anna Frida
core   +1 more source