Results 71 to 80 of about 118,592,744 (196)
Identification of COMMD1 as a novel lamin A binding partner [PDF]
, 2019 Lamin A, which is encoded by the LMNA gene, regulates gene expression and genome stability through interactions with a variety of proteins. Mutations in LMNA lead to a diverse set of inherited human diseases, collectively referred to as laminopathies. To
Liu, X +10 more
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Characterization of the cellular functions of the nucleoporins Nup153 and Nup88 [PDF]
, 2010 Characterization of the Cellular Functions of the Nucleoporins Nup153 and Nup88 PhD Thesis, Yvonne Christine Lussi, 2010, University of Basel Nuclear pore complexes (NPCs) and nuclear lamins are major constituents of the nuclear envelope (NE) in ...
Lussi, Yvonne Christine
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emilypujadas/Lamin-Project: v.1.0.0
<p><strong>Full Changelog</strong>: https://github.com/emilypujadas/Lamin-Project/commits/v.1.0.0</p ...
Nicolas Acosta +3 more
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The Transcriptomic and Genomic Analysis of Lamin A/C Expression in the Colon and in Colorectal Cancer [PDF]
, 2011 Lamins A and C, also known as A-type lamins, are type V nuclear intermediate filament proteins which form an interlacing meshwork of filaments subjacent to the inner nuclear membrane termed the nuclear lamina.
RAHMAN-CASANS, SYED,FIDA,UR +1 more
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Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]
, 2004 Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Kill, IR +3 more
core +2 more sources
iScienceSummary: Lamins A and C are components of the lamina at the nuclear periphery and associate with heterochromatin. A distinct, relatively mobile pool of lamin A/C in the nuclear interior associates with euchromatic regions and with lamin-associated ...
Daria Filipczak +4 more
doaj +1 more source
Nature CommunicationsAlterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the tumor microenvironment. Loss of the androgen receptor (AR) in human dermal
Soumitra Ghosh +8 more
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes [PDF]
, 2011 The premature ageing syndromes Hutchison-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are rare genetic disorders that result in greatly accelerated ageing. RD is neonatal fatal, whereas children suffering from HGPS age approximately 8
MUTER, JOANNE,RUTH
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The role of A-Type lamins and LAP2a in cellular ageing of human fibroblasts in vitro [PDF]
, 2005 Mutations in LMNA gene have been linked to a number of age-related tissue-specific diseases and premature ageing syndromes termed laminopathies. The finding that A- type lamins affect longevity and maintenance of a number of somatic tissues makes them ...
PekovicÌ, Vanja, Peković, Vanja
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Matrix stiffness induces midnolin-dependent lamin B1 degradation to control myoblast differentiation
EMBO ReportsCells decode mechanical cues to direct fate decisions through nuclear remodeling, yet nuclear adaptors to mechanical signals remain elusive. Here, we show that soft matrix suppresses myoblast differentiation and induces nuclear abnormality within 30 min,
Liping Guo +11 more
doaj +1 more source