Respiratory ResearchBackground Cellular senescence is one of the key steps in the progression of pulmonary fibrosis, and the senescence of type II alveolar epithelial cells (AEC IIs) may potentially accelerate the progression of pulmonary fibrosis.
Junhui Ba +9 more
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The effects of overexpression of lamin a and two mutants associated with premature aging on stem cell differentiation and proliferation. [PDF]
, 2007 The nuclear lamina is composed of A and B-type lamins and performs a number of functions within the nucleus. Mutations within lamins give rise to a group of diseases called laminopathies including autosomal dominant Emery-Dreifuss muscular dystrophy and ...
Gibbs-Seymour, Ian
core
ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
Cell ReportsSummary: LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely ...
Yuan Shen +10 more
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Protein kinase C activity modulates nuclear Lamin A/C dynamics in HeLa cells
Scientific ReportsThe nuclear lamina serves important functions in the nucleus, providing structural support to the nuclear envelope and contributing to chromatin organization. The primary proteins that constitute the lamina are nuclear lamins whose functions are impacted
Chase C. Wesley +2 more
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Lamin A/C-HDAC2 interplay during oxidative stress response
, 2015 By co-immunoprecipitation experiments and in situ proximity ligation assay, we determined a molecular interaction between HDAC2 and lamin A/C. Lamin A/C binds HDAC2 both in its native and in its phosphorylated form.
E Mattioli +4 more
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Functional characterization of LINC complex protein assemblies and their role in laminopathies [PDF]
, 2013 LINC (Linker of nucleoskeleton and cytoskeleton) complexes connect the nucleoskeleton to the cytoskeleton by interactions among LINC complex proteins and their interactions to proteins in the nucleus and the cytosol.
Yang, Liu
core
The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis. [PDF]
Biol CellFraboulet S, Aldarawish O, Dolega ME.
europepmc +1 more source
RanGAP1 coordinates the ER-lamina interface to drive de novo nuclear envelope reassembly in mouse embryos. [PDF]
Sci AdvZhang XJ +9 more
europepmc +1 more source
Herpesviruses show consistency in their nuclear egress-associated induction of lamina-depleted areas as measured in an autofluorescent reporter cell model. [PDF]
Virol JDhotre K +3 more
europepmc +1 more source