Results 1 to 10 of about 221,211 (337)

Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection [PDF]

JHEP Reports
Background & Aims: IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease. Anti-laminin 511-E8 autoantibodies have been identified in its pancreatic manifestation.
David C. Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F.J. van de Graaf, Ulrich Beuers   +5 more
doaj   +2 more sources

A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin [PDF]

Journal of Cell Biology, 1993
The dystrophin-glycoprotein complex was tested for interaction with several components of the extracellular matrix as well as actin. The 156-kD dystrophin-associated glycoprotein (156-kD dystroglycan) specifically bound laminin in a calcium-dependent ...
JM Ervasti, Kevin P. Campbell
openalex   +2 more sources

Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy. [PDF]

Nat Commun
McGowan TJ, Reinhard JR, Lewerenz N, Białobrzeska M, Lin S, Stępniewski J, Szade K, Dulak J, Rüegg MA.   +8 more
europepmc   +3 more sources

Structural mechanism of laminin recognition by integrin

Nature Communications, 2021
Recognition of laminin by integrin receptors is central to the epithelial cell adhesion to basement membrane, but the structural background of this molecular interaction remained elusive.
T. Arimori, N. Miyazaki, E. Mihara, Mamoru Takizawa, Yukimasa Taniguchi, C. Cabañas, K. Sekiguchi, J. Takagi   +7 more
semanticscholar   +1 more source

Comparison of Two Diagnostic Assays for Anti-Laminin 332 Mucous Membrane Pemphigoid

Frontiers in Immunology, 2021
Anti-laminin 332 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by predominant mucosal lesions and autoantibodies against laminin 332.
Stephanie Goletz, Federica Giurdanella, Maike M. Holtsche, Miranda Nijenhuis, Barbara Horvath, Gilles F. H. Diercks, Detlef Zillikens, Takashi Hashimoto, Enno Schmidt, Enno Schmidt, Hendri H. Pas   +10 more
doaj   +1 more source

Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice. [PDF]

PLoS ONE, 2012
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult ...
Tracy L Adair-Kirk, Gail L Griffin, Michelle J Meyer, Diane G Kelley, Jeffrey H Miner, Douglas R Keene, M Peter Marinkovich, J Michael Ruppert, Jouni Uitto, Robert M Senior   +9 more
doaj   +1 more source

Subunit-Specific Reactivity of Autoantibodies Against Laminin-332 Reveals Direct Inflammatory Mechanisms on Keratinocytes

Frontiers in Immunology, 2021
Laminin-332 pemphigoid is a rare and severe autoimmune blistering disease, caused by IgG autoantibodies targeting laminin-332 in the dermal-epidermal basement zone.
Lei Bao, Jing Li, Farzan Solimani, Farzan Solimani, Dario Didona, Payal M. Patel, Xiaoguang Li, Hua Qian, Norito Ishii, Takashi Hashimoto, Takashi Hashimoto, Michael Hertl, Kyle T. Amber, Kyle T. Amber   +13 more
doaj   +1 more source

Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics

Frontiers in Molecular Neuroscience, 2020
Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain.
Pamela Barraza-Flores, Christina R. Bates, Ariany Oliveira-Santos, Dean J. Burkin   +3 more
doaj   +1 more source

Laminin‐221 Enhances Therapeutic Effects of Human‐Induced Pluripotent Stem Cell–Derived 3‐Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Extracellular matrix, especially laminin‐221, may play crucial roles in viability and survival of human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPS‐CMs) after in vivo transplant.
Takaaki Samura, Shigeru Miyagawa, Takuji Kawamura, Satsuki Fukushima, Jun‐ya Yokoyama, Maki Takeda, Akima Harada, Fumiya Ohashi, Ryoko Sato‐Nishiuchi, Toshihiko Toyofuku, Koichi Toda, Kiyotoshi Sekiguchi, Yoshiki Sawa   +12 more
doaj   +1 more source

Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency. [PDF]

PLoS ONE, 2010
BACKGROUND: Laminin alpha2 chain mutations cause congenital muscular dystrophy with dysmyelination neuropathy (MDC1A). Previously, we demonstrated that laminin alpha1 chain ameliorates the disease in mice.
Kinga I Gawlik, Mikael Akerlund, Virginie Carmignac, Harri Elamaa, Madeleine Durbeej   +4 more
doaj   +1 more source