Results 31 to 40 of about 221,211 (337)

Cumulative prognostic power of laminin genes in colorectal cancer

BMC Medical Genomics, 2018
Background Laminins are a major family of extracellular matrix proteins and the main component of basement membranes. Laminins are involved in many if not all stages of cancer progression, and expression of laminin genes has prognostic value in various ...
Vladimir V. Galatenko, Diana V. Maltseva, Alexey V. Galatenko, Sergey Rodin, Alexander G. Tonevitsky   +4 more
doaj   +1 more source

The laminin family

Cell Adhesion & Migration, 2013
Laminins are large molecular weight glycoproteins constituted by the assembly of three disulfide-linked polypeptides, the α, β and γ chains. The human genome encodes 11 genetically distinct laminin chains.
M. Aumailley
semanticscholar   +2 more sources

CNS Neurons Deposit Laminin α5 to Stabilize Synapses

Cell Reports, 2017
Summary: Synapses in the developing brain are structurally dynamic but become stable by early adulthood. We demonstrate here that an α5-subunit-containing laminin stabilizes synapses during this developmental transition.
Mitchell H. Omar, Meghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske   +7 more
doaj   +1 more source

Tissue engineering a fetal membrane [PDF]

, 2011
The aim of this study was to construct an artificial fetal membrane (FM) by combination of human amniotic epithelial stem cells (hAESCs) and a mechanically enhanced collagen scaffold containing encapsulated human amniotic stromal fibroblasts (hASFs ...
Adam M. Squires, Anna L. David, Bipasha Chowdhury, Che John Connon, Connon C.J., Grinnell F., Ian William Hamley, Jones R.R., Kirkham S.M., Roanne Razalia Jones, Shengli Mi, Trinkaus R.V.   +11 more
core   +1 more source

The role of pericytic laminin in blood brain barrier integrity maintenance

Scientific Reports, 2016
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the ...
J. Gautam, Xuanming Zhang, Yao Yao
semanticscholar   +1 more source

Nondirected axonal growth on basal lamina from avian embryonic neural retina [PDF]

, 1987
The vitreous surface of the embryonic avian retinal neuroepithelium was isolated by mechanical disruption of the retina mounted between 2 adhesive substrata.
Halfter, W., Kröger, Stephan, Reckhaus, W.   +2 more
core   +1 more source

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures

Journal of Cell Biology, 1988
We have defined a signal responsible for the morphological differentiation of human umbilical vein and human dermal microvascular endothelial cells in vitro.
Yasuo Kubota, H. Kleinman, G. Martin, T. Lawley   +3 more
semanticscholar   +1 more source

Human Platelet Lysate Acts Synergistically With Laminin to Improve the Neurotrophic Effect of Human Adipose-Derived Stem Cells on Primary Neurons in vitro

Frontiers in Bioengineering and Biotechnology, 2021
BackgroundDespite the advancements in microsurgical techniques and noteworthy research in the last decade, peripheral nerve lesions have still weak functional outcomes in current clinical practice.
Martino Guiotto, Martino Guiotto, Wassim Raffoul, Andrew M. Hart, Andrew M. Hart, Mathis O. Riehle, Pietro G. di Summa   +6 more
doaj   +1 more source

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion [PDF]

, 2012
Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that
Hodgson, Lorna, Schmidt, Katy, Stephens, David J, Townley, Anna K   +3 more
core   +2 more sources

Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions

Frontiers in Molecular Neuroscience, 2020
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi, Hiroshi Nishimune, Hiroshi Nishimune   +2 more
doaj   +1 more source