Results 161 to 170 of about 15,070 (269)

Protein Kinase C Regulates Meiosis in Mammalian Oocytes

BioEssays, Volume 48, Issue 1, January 2026.
Protein kinase C (PKC) participates in the regulation of mammalian oocyte meiosis. PKC is involved in meiosis resumption in prophase I and in the stabilization of meiosis I and meiosis II spindles. PKC stimulates the maturation‐promoting factor during fertilization and stabilizes the mitotic spindle during early embryo development. ABSTRACT The protein
Jaroslav Kalous, Fatima J. Berro, Lucie Nemcova   +2 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Lamin: guardian against DNA damage by transcription stress. [PDF]

Cardiovasc Res
Jahng JWS, Wu JC.
europepmc   +1 more source

Phenolic Profile and In Vitro Anti‐Inflammatory Activities of Salvia officinalis L. Hydrodistillation Wastewater

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Hydrodistillation of Salvia officinalis L. generates wastewater enriched in polyphenolic compounds with biological activity. This study evaluates its anti‐inflammatory effects in vitro using LPS‐stimulated Raw 264.7 macrophages and E. coli‐challenged Caco‐2 cells.
Maria Sofia Molonia, Federica Lina Salamone, Francesco Cimino, Manuela D'Arrigo, Mariateresa Cristani, Luana Pulvirenti, Antonella Saija, Antonio Speciale, Edoardo Napoli   +8 more
wiley   +1 more source

Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing. [PDF]

Nucleus
Renkawitz J, Yesin A, Kroll J, Cabral AT, D'Annunzio S, Thiam HR.   +5 more
europepmc   +1 more source

Feedback regulation between histone H3 lysine 18 lactylation and TROP2‐mediated glycolysis drives metastatic progression of colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TROP2 is upregulated in CRC metastasis and promotes lactate overproduction via YBX1‐HIF‐1α signalling. TROP2 signalling induces H3K18la at metastasis genes promoters in CRC and promotes their expression. AccLactate sustains TROP2 expression in CRC cells via H3K18la Acriflavine suppresses TROP2‐driven CRLM by targeting the H3K18la/TROP2 feedback loop ...
Weifeng Wang, Yuxiang Deng, Weihao Li, Ruowei Wang, Chi Zhou, Yanbo Xu, Jiahua He, Le' en Liao, Jin Lan, Long Yu, Da Kang, Weili Zhang, Qingjian Ou, Zhizhong Pan, Yujing Fang, Peirong Ding, Junzhong Lin, Jianhong Peng   +17 more
wiley   +1 more source

Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations? [PDF]

Med Sci (Basel)
Erokhina MA, Vorotelyak EA, Vasiliev AV, Abdyev VK.   +3 more
europepmc   +1 more source

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss, Maria A. Lizarralde‐Iragorri, Thiago Trovati Maciel, Olivier Hermine   +3 more
wiley   +1 more source

New Roles of bZIP-Containing Membrane-Bound Transcription Factors in Chromatin Tethering and Karyoptosis. [PDF]

Int J Mol Sci
Jeung D, Li X, Cho YY.
europepmc   +1 more source

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source