Results 31 to 40 of about 9,918 (260)
Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins
Redox Biology, 2021 Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear ...
Gary S. Coombs +9 more
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Frontiers in Genetics, 2016 Lamins are intermediate filaments that form a complex meshwork at the inner nuclear membrane. Mammalian cells express two types of Lamins, Lamins A/C and Lamins B, encoded by three different genes, LMNA, LMNB1 and LMNB2.
Jérôme D. Robin, Frederique Magdinier
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Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
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A novel role of lamins from genetic disease to cancer biomarkers
Oncology Reviews, 2016 Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation.
Kunnathur Murugesan Sakthivel +1 more
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Nuclear lamins: Structure and function in mechanobiology
APL Bioengineering, 2022 Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm.
Amir Vahabikashi +3 more
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Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. [PDF]
PLoS Genetics, 2015 Mutations in the human LMNA gene cause muscular dystrophy by mechanisms that are incompletely understood. The LMNA gene encodes A-type lamins, intermediate filaments that form a network underlying the inner nuclear membrane, providing structural support ...
George Dialynas +9 more
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Post-Translational Modification of Lamins: Mechanisms and Functions
Frontiers in Cell and Developmental Biology, 2022 Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, regulation of cell cycle progression, regulation of spatial-
Mingyue Zheng +2 more
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Nuclear lamina strain states revealed by intermolecular force biosensor
Nature Communications, 2023 Nuclear lamins have been considered an important structural element of the nucleus. The nuclear lamina is thought both to shield DNA from excessive mechanical forces and to transmit mechanical forces onto the DNA.
Brooke E. Danielsson +8 more
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Lamins and lamin-associated proteins
Current Opinion in Cell Biology, 1994 A variety of morphological and biochemical studies have established that the nuclear lamins play an important role in nuclear structure and dynamics. Recent work reveals the existence of specialized lamin isotypes and novel pathways of modulation of lamin import into the nucleus via phosphorylation by protein kinase C.
Georgatos, S. D., Meier, J., Simos, G.
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Nuclear lamins and diabetes mellitus
STEMedicine, 2020 In metazoans, a thin filamentous network referred to as the nuclear lamina plays an essential role in providing mechanical support to the nucleus. The major constituent of the nuclear lamina is type V intermediate filament proteins that are collectively ...
Wei Xie, Brian Burke
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