Nuclear Lamins: Key Proteins for Embryonic Development
Biology, 2022 Lamins are essential components of the nuclear envelope and have been studied for decades due to their involvement in several devastating human diseases, the laminopathies.
Helena Fulka, Jasper Paul
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A Comparative Study of Drosophila and Human A-Type Lamins [PDF]
PLoS ONE, 2009 Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope. Lamins contain three domains: an N-terminal head, a central rod and a C-terminal tail domain possessing an Ig-fold structural ...
Caitrin W McDonough +2 more
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Nuclear Lamins in Cardiac Development and Disease [PDF]
CellsNuclear lamins organize the structural and regulatory architecture of the nucleus, integrating nuclear mechanics, chromatin organization, and genome regulation.
Siqi Li +4 more
doaj +2 more sources
A-type lamins involvement in transport and implications in cancer?
Nucleus, 2022 Nuclear lamins and transport are intrinsically linked, but their relationship is yet to be fully unraveled. A multitude of complex, coupled interactions between lamins and nucleoporins (Nups), which mediate active transport into and out of the nucleus ...
Sapun Parekh, Nicholas Ryan Scott
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A Perspective on the Experimental Techniques for Studying Lamins
Cells, 2017 Lamins are type V intermediate filaments that collectively form a meshwork underneath the inner nuclear membrane, called nuclear lamina. Furthermore, they are also present in the nucleoplasm. Lamins are experiencing a growing interest, since a wide range
Orfeo Sbaizero
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Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [PDF]
NucleusLamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery.
Jacob Odell +3 more
doaj +2 more sources
Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?
Cells, 2018 Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of
Nicolas Levy +2 more
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Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies
Cells, 2016 Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism.
Maitree Bhattacharyya +2 more
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Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]
, 2001 Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF +8 more
core +8 more sources
Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies [PDF]
CellsNuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska +3 more
doaj +2 more sources