Results 11 to 20 of about 9,924 (194)

The relationship of lamins with epigenetic factors during aging [PDF]

Вавиловский журнал генетики и селекции, 2022
The key factor of genome instability during aging is transposon dysregulation. This may be due to senile changes in the expression of lamins, which epigenetically modulate transposons. Lamins directly physically interact with transposons.
R. N. Mustafin, E. K. Khusnutdinova
doaj   +2 more sources

A comparative study of Drosophila and human A-type lamins. [PDF]

PLoS ONE, 2009
Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope. Lamins contain three domains: an N-terminal head, a central rod and a C-terminal tail domain possessing an Ig-fold structural ...
Sandra R Schulze, Beatrice Curio-Penny, Sean Speese, George Dialynas, Diane E Cryderman, Caitrin W McDonough, Demet Nalbant, Melissa Petersen, Vivian Budnik, Pamela K Geyer, Lori L Wallrath   +10 more
doaj   +3 more sources

Nuclear Lamins: Key Proteins for Embryonic Development

Biology, 2022
Lamins are essential components of the nuclear envelope and have been studied for decades due to their involvement in several devastating human diseases, the laminopathies.
Jasper Chrysolite Paul, Helena Fulka
doaj   +2 more sources

Nuclear Lamins in Cardiac Development and Disease [PDF]

Cells
Nuclear lamins organize the structural and regulatory architecture of the nucleus, integrating nuclear mechanics, chromatin organization, and genome regulation.
Siqi Li, Rui Li, Chun Liu, Dongzhu Xu, Lu Han   +4 more
doaj   +2 more sources

A novel role of lamins from genetic disease to cancer biomarkers

Oncology Reviews, 2016
Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation.
Kunnathur Murugesan Sakthivel, Poonam Sehgal   +1 more
doaj   +2 more sources

Nuclear lamins: Structure and function in mechanobiology [PDF]

APL Bioengineering, 2022
Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm.
Amir Vahabikashi, Stephen A. Adam, Ohad Medalia, Robert D. Goldman   +3 more
doaj   +2 more sources

Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [PDF]

Nucleus
Lamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery.
Jacob Odell, Kristen Nedza, Alexander Sopilniak-Mints, Jan Lammerding   +3 more
doaj   +2 more sources

Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies

Cells, 2016
Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism.
Subarna Dutta, Maitree Bhattacharyya, Kaushik Sengupta   +2 more
doaj   +2 more sources

Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]

, 2001
Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF, Vaughan, A, Hutchison, CJ, Wehnert, M, Bridger, JM, Morris, GE, Broers, JL, Raemakers, FC, Alvarez-Reyes, M   +8 more
core   +7 more sources

Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies [PDF]

Cells
Nuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska, Marta Rowińska, Aleksandra Tomczak, Ryszard Rzepecki   +3 more
doaj   +2 more sources