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The effect of Lamotrigin and Levetiracetam on the perinatal period [PDF]
, 2011 D. Wüller, U. Kalmus, H. Gerleve
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1995
Lamotrigine is a novel antiepileptic that, although its mechanism is not completely understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of the presynaptic release of the excitatory neurotransmitter glutamate. It is well absorbed after oral administration. Its route of elimination is hepatic glucuronidation, which is
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Lamotrigine is a novel antiepileptic that, although its mechanism is not completely understood, appears to affect voltage‐activated sodium channels, resulting in inhibition of the presynaptic release of the excitatory neurotransmitter glutamate. It is well absorbed after oral administration. Its route of elimination is hepatic glucuronidation, which is
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Clinical Neuropharmacology, 1994
Summary:Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbam‐azepine. In some models it appears to have a broader spectrum and better tolerability than these agents, however.
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Summary:Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbam‐azepine. In some models it appears to have a broader spectrum and better tolerability than these agents, however.
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Journal of Child Neurology, 1997
The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy. Lamotrigine exhibits first-order linear pharmacokinetics. Lamotrigine is well absorbed with bioavailability approaching 100%. The absorption is unaffected by food and there is no first-pass metabolism. The
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The pharmacokinetics of lamotrigine have been studied in single and multiple dose studies in animals, normal volunteers, and patients with epilepsy. Lamotrigine exhibits first-order linear pharmacokinetics. Lamotrigine is well absorbed with bioavailability approaching 100%. The absorption is unaffected by food and there is no first-pass metabolism. The
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Epilepsia, 1994
Summary: Clinical trials of lamotrigine (LTG) began in 1984. By November 1992 about 5,800 patient‐years' experience of adverse effects had been compiled. In general, LTG has an acceptable safety profile. Mild central nervous system adverse effects such as ataxia, dizziness, and headache occur significantly more frequently with LTG than with placebo ...
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Summary: Clinical trials of lamotrigine (LTG) began in 1984. By November 1992 about 5,800 patient‐years' experience of adverse effects had been compiled. In general, LTG has an acceptable safety profile. Mild central nervous system adverse effects such as ataxia, dizziness, and headache occur significantly more frequently with LTG than with placebo ...
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Lamotrigin-Intoxikation bei schwerer Präeklampsie
Zeitschrift für Geburtshilfe und Neonatologie, 2023V. Schaefer +6 more
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