Results 101 to 110 of about 18,858 (196)

Evaluation of GABAergic and Glutamatergic Levels in the Dorsal Anterior Cingulate Cortex of Patients With Bipolar Disorder: A Cross‐Sectional 1H‐MRS Study

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
Using 1H‐MRS with MEGA‐PRESS, we found no significant differences in dACC GABA or Glx levels between bipolar disorder patients and controls. However, GABA levels were higher in lithium‐treated patients, suggesting medication effects on GABAergic tone. ABSTRACT Background Imbalances between excitatory and inhibitory (E/I) neurotransmitters in the brain ...
Sotaro Moriyama, Yoshihiro Noda, Shiori Honda, Richard A. E. Edden, Koki Takahashi, Keisuke Saito, Keita Taniguchi, Masataka Wada, Sakiko Tsugawa, Yui Tobari, Sunjun Huh, Yumina Nakane, Saki Homma, Mie Matsui, Shinsuke Koike, Masaru Mimura, Hiroyuki Uchida, Shinichiro Nakajima   +17 more
wiley   +1 more source

Evaluating and Determining the Effects of Psychotropic Drugs on Motor Vehicle Driving Performance: Key Considerations of the Japanese Guideline and Criteria for Clinical Implementation of Evidence

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
The Japanese guideline and criteria for evaluating and determining the effects of psychotropic drugs on motor vehicle driving performance enable the clinical implementation of evidence by assessing “persistence of clinically meaningful impairment”. ABSTRACT The cross‐national differences in automobile driving precautions stated in psychotropic drug ...
Tetsuo Nakabayashi, Kunihiro Iwamoto, Akiko Yamaguchi, Yuki Konishi, Momoe Saji, Reiji Yoshimura, Kousuke Kanemoto, Hirofumi Aoki, Masahiko Ando, Norio Ozaki   +9 more
wiley   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 418-423, February 2026.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source

Collaboration in pharmacovigilance: lamotrigine and fatal severe cutaneous adverse reactions – a review of spontaneous reports

Therapeutics and Clinical Risk Management, 2017
Neil Brickel,1 Haris Shaikh,1 Andrew Kirkham,2 Greg Davies,1 Michelle Chalker,1 Pascal Yoshida3 1Global Clinical Safety and Pharmacovigilance, GlaxoSmithKline, Uxbridge, Middlesex, UK; 2Classic and Established Products, GlaxoSmithKline, Brentford ...
Brickel N, Shaikh H, Kirkham A, Davies G, Chalker M, Yoshida P   +5 more
doaj  

Timing of Secondary Palate Fusion in Human Embryos and Fetuses

Birth Defects Research, Volume 118, Issue 2, February 2026.
ABSTRACT Introduction The human face develops through a complex sequence of growth and fusion events involving multiple pharyngeal arch derivatives. Disruptions in these processes can result in congenital anomalies such as cleft lip and/or palate (CL/P), which occur in approximately 1.6 per 1000 live births in Europe.
Puck Pauline Mulder, Jess Johanna Peters, Yousif Dawood, Karl Jacobs, Sophie Caroline Visser, Jaco Hagoort, Jermo Hanemaaijer‐van der Veer, Robert Hemke, Eva Pajkrt, Roelof‐Jan Oostra, Corstiaan Cornelis Breugem, Bernadette Simone de Bakker   +11 more
wiley   +1 more source

Lamotrigine Effects on Breastfed Infants

Acta Medica Iranica, 2015
Lamotrigine is a safe anti-epileptic drug among pregnant and lactating women. Some concerns exist regarding the safety of lamotrigine during breastfeeding and related neonatal complications.
Hosein Dalili, Fatemeh Nayeri, Mamak Shariat, Leila Asgarzadeh   +3 more
doaj  

Case Report of Rasmussen's Encephalitis With a Decade of Refractory Epilepsy and Hemispheric Atrophy

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Rasmussen's encephalitis (RE) is a rare, chronic inflammatory neurological disorder affecting one cerebral hemisphere and presenting with drug‐resistant epilepsy, progressive hemiparesis, and cognitive decline. This case report describes the clinical course and management of a 21‐year‐old patient with refractory epilepsy and progressive ...
Sajjad Al‐Badri, Aditya Duhan, Rania H. Al‐Taie, Abbas Hamza Abbas, Ayah Abdulgadir, Ibrahim Khalil, Zaryab Bacha, Noran Al‐Gizey   +7 more
wiley   +1 more source

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 346-363, February 2026.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, Volume 22, Issue 8, 6 February 2026.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source

Lamotrigine, Contraceptives, and Psychiatry: A Narrative Review. [PDF]

Cureus
Costa I, Esteves-Sousa D.
europepmc   +1 more source