Results 51 to 60 of about 1,420,430 (337)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Plant material booklet 1: palms of Malaysia [PDF]

, 2001
This book is intended as quick reference for landscape architects, architects and urban planners in identifying palms for landscape planning and design of open spaces, recreational areas, residential landscape and street planting.
Abdul Rashid, Shahrulizam, Said, Ismail
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The Spatial Pattern Evolution of Urban Innovation Actors and the Planning Response to Path Dependency: A Case Study of Guangzhou City, China

Urban Science
The capacity for urban innovation is a significant symbol of contemporary urban development. In order to promote sustainable urban innovation, it is crucial to match and optimize innovation spaces, actors, and their behavioral needs.
Luhui Qi, Yuan Zhang, Yuanyi Chen, Lu Chen, Shuli Zhou, Xiaoli Wei   +5 more
doaj   +1 more source

Landscape Architectural Design as Scientific Inquiry? [PDF]

, 2011
This presentation discusses ‘landscape architectural design as scientific inquiry’ and exemplifies this with the description of a design process within climate-responsive design leading to new design knowledge.
Lenzholzer, S.
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Cultural elements’ influence on visual preferences in urban waterfronts’ walkways in Malaysia

Frontiers in Built Environment
With the rapid urbanization in Malaysia, human activities have caused damage to many waterfront areas. Efforts are being made to restore the connection between the community and river waterfronts while creating attractive urban spaces.
Tun Liu, Tun Liu, Mohd Yazid Mohd Yunos, Adam Aruldewan S. Muthuveeran, Riyadh Mundher, Nor Atiah Ismail   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Modelling and in vitro testing of the HIV-1 Nef fitness landscape. [PDF]

, 2019
An effective vaccine is urgently required to curb the HIV-1 epidemic. We have previously described an approach to model the fitness landscape of several HIV-1 proteins, and have validated the results against experimental and clinical data.
Barton, John P, Chakraborty, Arup K, Mahiti, Macdonald, Mann, Jaclyn K, Murakowski, Dariusz K, Mwimanzi, Phillip, Ndung'u, Thumbi, Rajkoomar, Erasha, Toyoda, Mako, Ueno, Takamasa   +9 more
core   +2 more sources