Results 61 to 70 of about 1,420,430 (337)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Empirical Research on Regional Revitalization: A Case of Old Urban Railways

Engineering Proceedings
Historically, railway facilities have been intertwined with daily life, communities, geography, and history, contributing to a rich cultural heritage and collective memory.
Wen-Bor Lu, Hsien-Wen Kuo, Chuan-Cheng Wang   +2 more
doaj   +1 more source

Sustainable Urban Landscape Management: An Insight Into Urban Green Space Management Practices in Three Different Countries

Journal of Landscape Ecology, 2019
To achieve high-quality urban landscape management, it is important to have a proper management system. Some developing countries like Afghanistan are facing a decline of green spaces due to lack of proper management.
Darkhani Faiza, Tahir Osman Mohd, Ibrahim Roziya   +2 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The importance of concept in the landscape design process in Malaysia. [PDF]

, 2010
Proper designs usually come from a sound concept, though some of Malaysian landscape design projects are carried out by disregarding its conceptual development. Therefore, concepts are not well defined and well-tied to their site context which results in
Baharuddin, Mohd Nasir, Kavousi, Shabnam, Krauss, Steven Eric, Maulan, Suhardi   +3 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Diurnal Variations in Greenspace Cooling Efficiency and Their Non-Linear Responses to Meteorological Change: Hourly Analysis of Air Temperature in Changsha, China

Atmosphere
Enhancing greenspace cooling efficiency (GCE) is a cost-effective nature-based solution to improve the urban thermal environment. The spatiotemporal patterns of GCE and their driving factors have been investigated mainly based on land surface temperature
Yang Li, Weiye Wang, Xin Li, Wei Liao, Xiaoma Li   +4 more
doaj   +1 more source

The Lampedusa Studio: A Multimethod Pedagogy for Tackling Compound Sustainability Problems in Architecture, Landscape Architecture, and Urban Design [PDF]

, 2020
Michael Hensel, Daniele Santucci, Defne Sunguroğlu Hensel, Thomas Auer   +3 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source