Results 61 to 70 of about 1,438,311 (284)

Modelling and in vitro testing of the HIV-1 Nef fitness landscape. [PDF]

, 2019
An effective vaccine is urgently required to curb the HIV-1 epidemic. We have previously described an approach to model the fitness landscape of several HIV-1 proteins, and have validated the results against experimental and clinical data.
Barton, John P, Chakraborty, Arup K, Mahiti, Macdonald, Mann, Jaclyn K, Murakowski, Dariusz K, Mwimanzi, Phillip, Ndung'u, Thumbi, Rajkoomar, Erasha, Toyoda, Mako, Ueno, Takamasa   +9 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Empirical Research on Regional Revitalization: A Case of Old Urban Railways

Engineering Proceedings
Historically, railway facilities have been intertwined with daily life, communities, geography, and history, contributing to a rich cultural heritage and collective memory.
Wen-Bor Lu, Hsien-Wen Kuo, Chuan-Cheng Wang   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Sustainable Urban Landscape Management: An Insight Into Urban Green Space Management Practices in Three Different Countries

Journal of Landscape Ecology, 2019
To achieve high-quality urban landscape management, it is important to have a proper management system. Some developing countries like Afghanistan are facing a decline of green spaces due to lack of proper management.
Darkhani Faiza, Tahir Osman Mohd, Ibrahim Roziya   +2 more
doaj   +1 more source

A sustainable tourism development in Alacati, Turkey : (Re)invention of public space with clean energy [PDF]

, 2013
Although there is an increasing recognition of the impacts of climate change on communities, residents often resist changing their lifestyle to reduce the effects of the problem.
Buys, Laurie, Ozgun, Kaan
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Diurnal Variations in Greenspace Cooling Efficiency and Their Non-Linear Responses to Meteorological Change: Hourly Analysis of Air Temperature in Changsha, China

Atmosphere
Enhancing greenspace cooling efficiency (GCE) is a cost-effective nature-based solution to improve the urban thermal environment. The spatiotemporal patterns of GCE and their driving factors have been investigated mainly based on land surface temperature
Yang Li, Weiye Wang, Xin Li, Wei Liao, Xiaoma Li   +4 more
doaj   +1 more source

Designing socially sound poultry farming : matching hen ethology, farm management and landcape quality [PDF]

, 2011
: In order to receive a licence to produce, poultry farmers have to take into account societal demands, among others: animal welfare, healthy working conditions for the workers and landscape quality.
Stobbelaar, D.J.
core   +1 more source