Results 91 to 100 of about 942,623 (281)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Birds of Berlin: Changes in communities and guilds in the urban park “Tiergarten” since 1850

Ecology and Evolution
Urbanization has far‐reaching consequences on birds, and knowledge of the impacts on taxonomic and functional diversity is necessary to make cities as compatible as possible for species.
Esther Sophie Felgentreff, Nadja Pernat, Sascha Buchholz   +2 more
doaj   +1 more source

Modelling the geomorphic history of the Tribeč Mts. and the Pohronský Inovec Mts. (Western Carpathians) with the CHILD model

Open Geosciences, 2016
Numerical models were developed in order to provide a suitable computational framework for exploring research questions related to long-term landscape evolution.
Staškovanová Veronika, Minár Jozef
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Continuity in morphological disparity in tropical reef fishes across evolutionary scales

Communications Biology
Tropical reef fishes exhibit a large disparity of organismal morphologies contributing to their astonishing biodiversity. Morphological disparity, scaling from differences among individuals within populations to differences among species, is governed by ...
Giulia Francesca Azzurra Donati, Camille Albouy, Thomas Claverie, David Mouillot, Rodney Govinden, Oskar Hagen, Shameel Ibrahim, Julius Pagu, Irthisham Zareer, Fabien Leprieur, Loïc Pellissier   +10 more
doaj   +1 more source

Geoarchaeology and PalaeoDEMs Modelling to Assess the Archaeological Potential of Ravenna and Its Hinterland

Journal of Open Archaeology Data
This paper presents a collection of nine datasets developed as part of a PhD research project in Archaeology to investigate landscape transformations in the hinterland of Ravenna.
Michele Abballe
doaj   +1 more source

Continuum Model for River Networks

, 1995
The effects of erosion, avalanching and random precipitation are captured in a simple stochastic partial differential equation for modelling the evolution of river networks.
A. Czirok, A. E. Scheidegger, A. Rinaldo, A. Rinaldo, Achille Giacometti, Amos Maritan, G. I. Barenblatt, H. Inaoka, H. Takayasu, I. Rodriguez-Iturbe, J. E. Green, Jayanth R. Banavar, M. Fisher, P. Bak, P. Meakin, R. E. Horton, R. Leheny, S. F. Edwards, S. Kramer, T. Nagatani, T. R. Smith, W. S. Glock   +21 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Regional uniqueness of tree species composition and response to forest loss and climate change

Nature Communications
The conservation and restoration of forest ecosystems require detailed knowledge of the native plant compositions. Here, we map global forest tree composition and assess the impacts of historical forest cover loss and climate change on trees.
Nina van Tiel, Fabian Fopp, Philipp Brun, Johan van den Hoogen, Dirk Nikolaus Karger, Cecilia M. Casadei, Lisha Lyu, Devis Tuia, Niklaus E. Zimmermann, Thomas W. Crowther, Loïc Pellissier   +10 more
doaj   +1 more source