Results 111 to 120 of about 942,623 (281)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Landscape evolution under the southern Laurentide Ice Sheet. [PDF]

Sci Adv, 2021
Naylor S, Wickert AD, Edmonds DA, Yanites BJ.   +3 more
europepmc   +1 more source

Hierarchical Crossover and Probability Landscapes of Genetic Operators

, 1995
The time evolution of a simple model for crossover is discussed. A variant of this model with an improved exploration behavior in phase space is derived as a subset of standard one- and multi-point crossover operations.
Bornholdt, Stefan, Schuster, Heinz Georg
core   +1 more source

Dynamical TAP approach to mean field glassy systems

, 1999
The Thouless, Anderson, Palmer (TAP) approach to thermodynamics of mean field spin-glasses is generalised to dynamics. A method to compute the dynamical TAP equations is developed and applied to the p-spin spherical model. In this context we show to what
, Barrat A, Barrat A, Barrat A, Biroli G, Bouchaud J P, Bouchaud J P, Bray A, Crisanti A, Crisanti A, Crisanti A, Cugliandolo L F, Cugliandolo L F, De Dominicis C, Franz S, Franz S, Franz S, Georges A, Giulio Biroli, Götze W, Haymaker R W, Heerema M, Heerema M, Kirkpatrick T R, Kurchan J, Kurchan J, Kurchan J, Lopatin A V, Martin P C, Metha M L, Mézard M, Mézard M, Parisi G, Parisi G, Parisi G, Parisi G, Plefka T, Sommers H J, Thouless D J, Thouless D J, Zinn-Justin J   +40 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Coupled influence of tectonics, climate, and surface processes on landscape evolution in southwestern North America. [PDF]

Nat Commun, 2022
Bahadori A, Holt WE, Feng R, Austermann J, Loughney KM, Salles T, Moresi L, Beucher R, Lu N, Flesch LM, Calvelage CM, Rasbury ET, Davis DM, Potochnik AR, Ward WB, Hatton K, Haq SSB, Smiley TM, Wooton KM, Badgley C.   +19 more
europepmc   +1 more source

Aggregation of stochastic models [PDF]

, 2007
Dstl examines battle simulations based on stochastic evolution codes. One such code, known as SIMBAT (SIMple BATtle program) models the evolution of the battle as a sequence of turns in which the two sets of combating units move in a landscape. The units
Hjorth, Poul
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Landscape Evolution and It's Impact of Ecosystem Service Value of the Wuhan City, China. [PDF]

Int J Environ Res Public Health, 2021
Chen R, Huang C.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source