Results 41 to 50 of about 61,815 (267)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mathematical Modeling and Parameter Estimation of Lane-Changing Vehicle Behavior Decisions

Mathematics
Lane changing is a crucial scenario in traffic environments, and accurately recognizing and predicting lane-changing behavior is essential for ensuring the safety of both autonomous vehicles and drivers.
Jianghui Wen, Yebei Xu, Min Dai, Nengchao Lyu   +3 more
doaj   +1 more source

Target Vehicle Selection Algorithm for Adaptive Cruise Control Based on Lane-changing Intention of Preceding Vehicle

Chinese Journal of Mechanical Engineering, 2021
To improve the ride comfort and safety of a traditional adaptive cruise control (ACC) system when the preceding vehicle changes lanes, it proposes a target vehicle selection algorithm based on the prediction of the lane-changing intention for the ...
Jun Yao, Guoying Chen, Zhenhai Gao
doaj   +1 more source

Effects of Langmuir Kinetics of Two-Lane Totally Asymmetric Exclusion Processes in Protein Traffic

, 2007
In this paper, we study a two-lane totally asymmetric simple exclusion process (TASEP) coupled with random attachment and detachment of particles (Langmuir kinetics) in both lanes under open boundary conditions. Our model can describe the directed motion
Alberts A., Howard J., JIMING LIU, MINGZHE LIU, QING-SONG WU, RUI JIANG, RUILI WANG   +6 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Research on Mandatory Lane-Changing Behavior in Highway Weaving Sections

Journal of Advanced Transportation, 2020
As the accident-prone sections and bottlenecks, highway weaving sections will become more complicated when it comes to the mixed-traffic environments with connected and automated vehicles (CAVs) and human-driven vehicles (HVs).
Wei Hao, Zhaolei Zhang, Zhibo Gao, Kefu Yi, Li Liu, Jie Wang   +5 more
doaj   +1 more source

Influencing Factors of the Length of Lane-Changing Buffer Zone for Autonomous Driving Dedicated Lanes

Applied Sciences, 2022
With the development of intelligent transportation, dedicated highway lanes for autonomous vehicles (AVs), necessary for ensuring their right of way, have emerged as critical issues in intelligent transportation research, which makes it necessary to set ...
Fujin Hou, Ying Zhang, Shujian Wang, Zhengxi Shen, Peipei Mao, Xu Qu   +5 more
doaj   +1 more source

Line-of-Sight Obstruction Analysis for Vehicle-to-Vehicle Network Simulations in a Two-Lane Highway Scenario [PDF]

, 2013
In vehicular ad-hoc networks (VANETs) the impact of vehicles as obstacles has largely been neglected in the past. Recent studies have reported that the vehicles that obstruct the line-of-sight (LOS) path may introduce 10-20 dB additional loss, and as a ...
Abbas, Taimoor, Tufvesson, Fredrik
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source