Results 71 to 80 of about 270,632 (283)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Attention-based Lane Change Prediction [PDF]
2019 International Conference on Robotics and Automation (ICRA), 2019 Lane change prediction of surrounding vehicles is a key building block of path planning. The focus has been on increasing the accuracy of prediction by posing it purely as a function estimation problem at the cost of model understandability. However, the efficacy of any lane change prediction model can be improved when both corner and failure cases are
Oliver Scheel +4 more
openaire +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Investigation of Thermal Stimuli for Lane Changes [PDF]
Proceedings of the 10th International Conference on Automotive User Interfaces and Interactive Vehicular Applications, 2018 Haptic feedback has been widely studied for in-car interactions.\ud However, most of this research has used vibrotactile cues.\ud This paper presents two studies that examine novel thermal\ud feedback for navigation during simulated driving for a lane\ud change task.
Patrizia Di Campli San Vito +5 more
openaire +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The New Italian Road Code and the virtues of the ‘shame lane’ [PDF]
In July 2003 a new Road Code was approved by the Italian parliament. Among many reforms whose validity is not questioned here, the new law states that on three-lane motorways the right lane should not be reserved anymore to slow vehicles alone. As in two-
Matteo Richiardi
core +2 more sources
-XXX 1 TACTICAL LANE CHANGE MODEL WITH SEQUENTIAL MANEUVER PLANNING [PDF]
, 2020 The lane change models used in today's traffic simulators often do not determine lane change actions in terms of the evaluation of sequential plans, but rather in terms of the utility of the very next lane change action. This has the disadvantage of
Masao Kuwahara +2 more
core
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source