Results 51 to 60 of about 270,632 (283)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Discretionary Lane-Change Decision and Control via Parameterized Soft Actor–Critic for Hybrid Action Space

Machines
This study focuses on a crucial task in the field of autonomous driving, autonomous lane change. Autonomous lane change plays a pivotal role in improving traffic flow, alleviating driver burden, and reducing the risk of traffic accidents. However, due to
Yuan Lin, Xiao Liu, Zishun Zheng
doaj   +1 more source

Classification of Automated Lane-Change Styles by Modeling and Analyzing Truck Driver Behavior: A Driving Simulator Study

IEEE Open Journal of Intelligent Transportation Systems, 2022
Lane change is a highly demanding driving task. A number of traffic accidents are induced by erroneous maneuvers. An automated lane-change system has the potential to reduce the driver workload and improve driving safety.
Zheng Wang, Muhua Guan, Jin Lan, Bo Yang, Tsutomu Kaizuka, Junichi Taki, Kimihiko Nakano   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

SUMO’s Lane-Changing Model [PDF]

, 2015
SUMO is an open source microscopic traffic simulation. A major component of modelling microscopic vehicle behavior is the lane-changing behavior on multi-lane roads. We describe a new model which uses a 4-layered hierarchy of motivations to determine the vehicle behavior during every simulation step and motivate in which ways it improves the current ...
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Research on Safety Lane Change Warning Method Based on Potential Angle Collision Point

Journal of Advanced Transportation, 2019
In order to ensure safe lane change and avoid traffic accidents, an effective lane change assist system is required. In a lane change assist system, it is very important to obtain the following elements in time, such as actual distance between vehicles ...
Tongqiang Ding, Xiaorong Li, Lili Zheng, Zhiguo Hao   +3 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Study on Lane-Change Replanning and Trajectory Tracking for Intelligent Vehicles Based on Model Predictive Control

World Electric Vehicle Journal, 2023
When an intelligent vehicle changes lanes, the state of other vehicles may change, which increases the risk of collision. Therefore, real-time local path replanning is needed at this time. Based on model predictive control (MPC), a lane-change trajectory
Yaohua Li, Dengwang Zhai, Jikang Fan, Guoqing Dong   +3 more
doaj   +1 more source