Results 91 to 100 of about 1,897,464 (299)

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis

Advanced Materials, EarlyView.
Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne, Julian S. Hertel, André Delavault, Judith Felk, Martin Peng, Lara Reuber, Felix Ott, Kim Wanner, Marc F. Münker, Adrian Neukirch, Alexei Kiselev, Kersten S. Rabe, Christof M. Niemeyer   +12 more
wiley   +1 more source

Technical Feasibility Study of Autonomous Field Robot‐Based on‐the‐go Assessment of Soil Nutrients Using Ion‐Sensitive Field‐Effect Transistors

Advanced Robotics Research, EarlyView.
Autonomous field robots equipped with ISFET‐based sensors enable rapid, spatially resolved soil nutrient analysis directly in the field. An automated system based on the BoniRob platform is presented for standardized on‐site extraction and measurement of key macronutrients and soil pH.
Vadim Riedel, Stefan Hinck, Edgar Peiter, Arno Ruckelshausen   +3 more
wiley   +1 more source

Lane County : Transportation system plan [PDF]

, 2004
231 pp. Item contains two files. Plan and appendices are in one file; referenced maps are included in a separate file. Bookmarks modified by UO. Effective June 4, 2004.
Lane County (Or.), Lane County (Or.). Public Works Dept.   +1 more
core   +1 more source

Accountability: The Fast Lane on the Highway to Change

American Journal of Public Health, 2009
The authors suggest that accountability through accreditation on the part of public health departments may offer a competitive marketplace advantage for government and encourage improvement of the health care system. They mention that the Public Health Accreditation Board (PHAB) in collaboration with national partners and the public health community ...
Leslie M, Beitsch, Liza C, Corso
openaire   +3 more sources

Lane-Changing Model in SUMO [PDF]

, 2014
SUMO is an open source microscopic traffic simulation. A major component of modelling microscopic vehicle behavior is the lane-changing behavior on multi-lane roads. We describe a new model which uses a 4-layered hierarchy of motivations to determine the
Erdmann, Jakob
core  

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Lane Detection and Lane-Changing Identification with High-Resolution Data from a Swarm of Drones [PDF]

In the era of big data, new transportation-related concepts and methodologies need to be proposed to understand how congestion propagates. pNEUMA, a unique dataset that was acquired during a first-of-its-kind experiment using a swarm of drones over a ...
Sauvin, Guillaume M., Barmpounakis, Emmanouil, Geroliminis, Nikolaos   +2 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source