Results 71 to 80 of about 1,897,464 (299)
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Lane-changing risk analysis of passenger cars on highways based on the HighD dataset
Shenzhen Daxue xuebao. Ligong banTo investigate the microscopic lane-changing behavior characteristics and associated risk for passenger cars on highways, we extracted lane-changing trajectories of the subject vehicle and driving data of surrounding vehicles from the HighD dataset.
LIU Tong +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Lane County Notice of Adopted Amendment (2009-06-24)
, 2009 37 pp. Adopted 2009-06-24. Department of Land Conservation and Development Notice of Adopted AmendmentThe ten small cities of Lane County have applied for a PAPA to the Lane County Rural Comprehensive Plan (RCP) to adopt a coordinated 20 year population ...
Lane County (Or.)
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Lane Collection - Lane Family Portrait at "Willowhurst", circa 1910
, 1910 Left to right: Edythe Lane, Ernest Erastus Lane, Maude Lane, and Abbie Waldron Lane on the front lawn of Willowhurst, the Lane family home in ...
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Analysis of Highway Vehicle Lane Change Duration Based on Survival Model
Big Data and Cognitive ComputingTo investigate highway vehicle lane-changing behavior, we utilized the publicly available naturalistic driving dataset, HighD, to extract the movement data of vehicles involved in lane changes and their proximate counterparts.
Sheng Zhao +3 more
doaj +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, EarlyView.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
Oral History Interview with Bill Lane, April 1, 2006
, 2006 The National Museum of the Pacific War presents an oral interview with Bill Lane. Lane was attending the University of Texas and tried joining the Marine Corps, but did not pass the physical. He instead opted for the Army, which accepted him.
Lane, Bill
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