Results 51 to 60 of about 15,353,657 (286)

An Integrated Fuzzy Analytic Hierarchy Process (AHP) Model for Studying Significant Factors Associated with Frequent Lane Changing

Entropy, 2022
Frequent lane changes cause serious traffic safety concerns, which involve fatalities and serious injuries. This phenomenon is affected by several significant factors related to road safety.
Sarbast Moslem, Danish Farooq, Arshad Jamal, Yahya Almarhabi, Meshal Almoshaogeh, Farhan Muhammad Butt, Rana Faisal Tufail   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Exploring Sustainable Lane-Change Behaviours – Integrated Approach to Modelling Mixed Traffic with Intelligent-Connected Vehicles

Promet (Zagreb)
This paper proposes two sustainable lane-changing (LC) decision-making models for application in intelligent-connected (I-C) and mixed-traffic environments.
Xushan FANG, Peikun LIAN, Wei HUANG, Chao WANG, Said M. EASA, Shuang LIN, Ning CHEN   +6 more
doaj   +1 more source

Driver Lane-Changing Behavior Prediction Based on Deep Learning

Journal of Advanced Transportation, 2021
A correct lane-changing plays a crucial role in traffic safety. Predicting the lane-changing behavior of a driver can improve the driving safety significantly. In this paper, a hybrid neural network prediction model based on recurrent neural network (RNN)
Cheng Wei, Fei Hui, Asad J. Khattak
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Multi-lane Changing Model with Coupling Driving Intention and Inclination [PDF]

, 2017
Considering the impact of drivers’ psychology and behaviour, a multi-lane changing model coupling driving intention and inclination is proposed by introducing two quantitative indices of intention: strength of lane changing and risk factor.
Gao, Chang, Jiangfeng Wang, Zhouyuan Zhu, Wang, Jiangfeng, Chang Gao, Xuedong Yan, Yan, Xuedong, Zhu, Zhouyuan   +7 more
core   +1 more source

QPNet: Lane‐changing trajectory planning combining quadratic programming and neural network under the convex optimization framework

IET Intelligent Transport Systems, 2022
Lane‐changing is a basic driving behaviour, which largely impacts on traffic safety and efficiency. With the development of technology, the automated lane‐changing system has attracted extensive attention.
Ying Wang, Chong Wei, Shurong Li
doaj   +1 more source

Characteristic Analysis and Decision Model of Lane-Changing Game for Intelligent Connected Vehicles

Applied Sciences, 2023
To study the lane-change interaction characteristics of intelligent connected vehicles (ICVs) and reduce the risk of vehicle lane-changing decisions, a decision model based on the lane-changing game characteristics of the ICV is proposed in this paper ...
Dayi Qu, Shouchen Dai, Aodi Li, Yicheng Chen, Chuanbao Wei   +4 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source